Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.32 |
| ▸ | YAP1 | P46937 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4598388 | 0.89 | ADORA1 (0.34) | TACR1RORCGPR119NR1H2 | |
| SCHEMBL4598172 | 0.79 | REN (0.39) | GPR119 | |
| SCHEMBL4941015 | 0.76 | REN (0.44) | — | |
| SCHEMBL4611135 | 0.74 | REN (0.36) | KIT | |
| SCHEMBL4934280 | 0.71 | NR1H2 (0.41) | RORCGPR119NR1H2 | |
| SCHEMBL2404304 | 0.71 | NAMPT (0.52) | KITGPR119 | |
| SCHEMBL4598320 | 0.70 | CHRM5 (0.38) | L3MBTL1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL4930538 | 0.67 | REN (0.45) | RORC | |
| SCHEMBL4938688 | 0.66 | REN (0.45) | — | |
| SCHEMBL4597868 | 0.66 | RARG (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1908471-A1 | Tetrahydropyridines as renin inhibitors | Speedel Experimenta AG (CH) | 2008-04-09 | — | — | EP | disclosed |