Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 11/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8450949 | 0.81 | REN (0.57) | RENCYP3A4 | |
| SCHEMBL4598109 | 0.79 | TACR1 (0.35) | GPR119 | |
| SCHEMBL4598388 | 0.78 | ADORA1 (0.34) | GPR119 | |
| SCHEMBL8450331 | 0.77 | REN (0.57) | RENCYP3A4 | |
| SCHEMBL8450946 | 0.77 | REN (0.58) | RENCYP3A4 | |
| SCHEMBL4598184 | 0.77 | GPR119 (0.38) | RENGPR119CYP3A4HTR2A | |
| SCHEMBL4598190 | 0.70 | REN (0.35) | RENGPR119CYP3A4 | |
| SCHEMBL4941015 | 0.69 | REN (0.44) | RENCYP3A4 | |
| SCHEMBL4939031 | 0.68 | REN (0.44) | RENCYP3A4 | |
| SCHEMBL8231181 | 0.67 | REN (0.66) | RENCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1908471-A1 | Tetrahydropyridines as renin inhibitors | Speedel Experimenta AG (CH) | 2008-04-09 | — | — | EP | disclosed |