Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 1/20 | 0.46 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 13/20 | 0.35 |
| ▸ | CDC14B | O60729 | 1/20 | 0.33 |
| ▸ | CDC14A | Q9UNH5 | 1/20 | 0.33 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4343407 | 0.74 | GABBR2 (0.47) | GABBR2GABBR1PDK2 | |
| SCHEMBL2826346 | 0.73 | GABBR2 (0.64) | GABBR2GABBR1PDK2 | |
| SCHEMBL2826349 | 0.73 | GABBR2 (0.64) | GABBR2GABBR1PDK2 | |
| SCHEMBL2826352 | 0.73 | GABBR2 (0.64) | GABBR2GABBR1PDK2 | |
| SCHEMBL2829664 | 0.69 | GABBR2 (0.58) | GABBR2GABBR1 | |
| SCHEMBL2829666 | 0.69 | GABBR2 (0.58) | GABBR2GABBR1 | |
| SCHEMBL2829669 | 0.69 | GABBR2 (0.58) | GABBR2GABBR1 | |
| SCHEMBL2834138 | 0.68 | GABBR2 (0.56) | GABBR2GABBR1PDK2PTPN5 | |
| SCHEMBL2829154 | 0.63 | GABBR2 (0.74) | GABBR2GABBR1PDK2 | |
| SCHEMBL2371847 | 0.63 | GABBR2 (1.00) | GABBR2GABBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1915357-A1 | 2-HYDROXY-PROPIONIC ACID DERIVATIVES AND 3-HYDROXY-BENZOFURAN-2-ONE DERIVATIVES WITH AFFINITY FOR THE GABA-B-RECEPTOR | F. Hoffmann-Roche AG (CH) | 2008-04-30 | — | — | EP | disclosed |
| WO-2007014843-A1 | 2-HYDROXY-PROPIONIC ACID DERIVATIVES AND 3-HYDROXY-BENZOFURAN-2-ONE DERIVATIVES WITH AFFINITY FOR THE GABA-B-RECEPTOR | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-08 | — | — | WO | disclosed |