Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 1/20 | 0.58 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.58 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.37 |
| ▸ | GLRB | P48167 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | EEF2K | O00418 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TYR | P14679 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GALR3 | O60755 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2829664 | 1.00 | GABBR2 (0.58) | GABBR2GABBR1GLRA3GLRBPTGS1 | |
| SCHEMBL2829666 | 1.00 | GABBR2 (0.58) | GABBR2GABBR1GLRA3GLRBPTGS1 | |
| SCHEMBL2829152 | 0.73 | GABBR2 (0.74) | GABBR2GABBR1PTGS1PTGS2CA2 | |
| SCHEMBL2829157 | 0.73 | GABBR2 (0.74) | GABBR2GABBR1PTGS1PTGS2CA2 | |
| SCHEMBL2371847 | 0.73 | GABBR2 (1.00) | GABBR2GABBR1 | |
| SCHEMBL2371840 | 0.73 | GABBR2 (1.00) | GABBR2GABBR1 | |
| SCHEMBL30618192 | 0.73 | GABBR2 (1.00) | GABBR2GABBR1 | |
| SCHEMBL2371842 | 0.73 | GABBR2 (1.00) | GABBR2GABBR1 | |
| SCHEMBL2829154 | 0.73 | GABBR2 (0.74) | GABBR2GABBR1PTGS1PTGS2CA2 | |
| SCHEMBL2831254 | 0.70 | GABBR2 (0.69) | GABBR2GABBR1PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1915357-B1 | 2-HYDROXY-PROPIONIC ACID DERIVATIVES AND 3-HYDROXY-BENZOFURAN-2-ONE DERIVATIVES WITH AFFINITY FOR THE GABA-B-RECEPTOR | HOFFMANN LA ROCHE (CH) | 2010-09-08 | — | — | EP | claimed |
| US-7504428-B2 | 2-phenyl-3,3,3-trifluoro-2-hydroxy-propionic acid derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-03-17 | — | — | US | claimed |
| US-20080234356-A1 | 2-PHENYL-3,3,3-TRIFLUORO-2-HYDROXY-PROPIONIC ACID DERIVATIVES | MALHERBE PARICHEHR | 2008-09-25 | — | — | US | claimed |
| US-20070027204-A1 | 2-phenyl-3,3,3-trifluoro-2-hydroxy-propionic acid derivatives | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2007-02-01 | — | — | US | claimed |
| EP-1915357-B1 | 2-HYDROXY-PROPIONIC ACID DERIVATIVES AND 3-HYDROXY-BENZOFURAN-2-ONE DERIVATIVES WITH AFFINITY FOR THE GABA-B-RECEPTOR | HOFFMANN LA ROCHE (CH) | 2010-09-08 | — | — | EP | disclosed |
| US-7504428-B2 | 2-phenyl-3,3,3-trifluoro-2-hydroxy-propionic acid derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-03-17 | — | — | US | disclosed |
| US-20080234356-A1 | 2-PHENYL-3,3,3-TRIFLUORO-2-HYDROXY-PROPIONIC ACID DERIVATIVES | MALHERBE PARICHEHR | 2008-09-25 | — | — | US | disclosed |
| US-7396853-B2 | 2-phenyl-3,3,3-trifluoro-2-hydroxy-propionic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-07-08 | — | — | US | disclosed |
| US-20070027204-A1 | 2-phenyl-3,3,3-trifluoro-2-hydroxy-propionic acid derivatives | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027204-A1 | 2-phenyl-3,3,3-trifluoro-2-hydroxy-propionic acid derivatives | GABRA3, GABRA2, GABRA1 | GABBR2 6/4885GABBR1 4/4885GLRA3 28/4885 |
| US-20080234356-A1 | 2-PHENYL-3,3,3-TRIFLUORO-2-HYDROXY-PROPIONIC ACID DERIVATIVES | GABBR1, GABRA2, GABRA3 | GABBR2 5/4885GABBR1 1/4885GLRA3 52/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.