SCHEMBL4598728

SCHEMBL4598728

Cc1cc(Sc2ccc(CO)c(C)n2)ccc1Br

nearest known ligand 0.33

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
MAPT P10636 2/20 0.32
LMNA P02545 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
TP53 P04637 1/20 0.31
F2 P00734 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4598334 0.80 MEN1 (0.32) MEN1KMT2A
SCHEMBL4597346 0.77 SMN1; SMN2 (0.36) MEN1KMT2AMAPTLMNAL3MBTL1
SCHEMBL4596641 0.76 MAPT (0.34) MEN1KMT2AMAPTTP53F2
SCHEMBL4598335 0.73
SCHEMBL10595472 0.71 ALDH1A1 (0.40) MEN1KMT2AMAPTLMNAL3MBTL1
SCHEMBL19846093 0.67 LMNA (0.44) MEN1KMT2AMAPTLMNATP53
SCHEMBL19284172 0.66 MEN1 (0.41) MEN1KMT2ALMNA
SCHEMBL27370766 0.66 HAO1 (0.37) KMT2A
SCHEMBL594758 0.65 MCL1 (0.41) MAPTLMNAL3MBTL1
SCHEMBL19846087 0.64 HPGD (0.41) MEN1KMT2AMAPTLMNAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1924265-A2 CHEMOKINE RECEPTOR BINDING COMPOUNDS Genzyme Corporation (US) 2008-05-28 EP disclosed
US-20070066624-A1 Chemokine receptor binding compounds ANORMED, INC. (CA) 2007-03-22 US disclosed
WO-2007022371-A2 CHEMOKINE RECEPTOR BINDING COMPOUNDS GENZYME CORPORATION (US) 2007-02-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070066624-A1 Chemokine receptor binding compounds CCR5, CCR4, CCR1 MEN1 4855/4885KMT2A 4627/4885MAPT 3432/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.