Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.72 |
| ▸ | GAA | P10253 | 7/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.72 |
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.64 |
| ▸ | TSHR | P16473 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.50 |
| ▸ | XBP1 | P17861 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14544125 | 0.86 | ALDH1A1 (0.56) | ALDH1A1GAAKDM4EMAPTTDP1 | |
| SCHEMBL9417094 | 0.82 | ALDH1A1 (0.90) | ALDH1A1GAAKDM4EMAPTTDP1 | |
| SCHEMBL2164001 | 0.82 | ALDH1A1 (0.72) | ALDH1A1GAAKDM4EMAPTTDP1 | |
| SCHEMBL30951303 | 0.81 | ALDH1A1 (0.70) | ALDH1A1GAAKDM4EMAPTTDP1 | |
| SCHEMBL5571042 | 0.79 | ALDH1A1 (0.97) | ALDH1A1GAAKDM4EMAPTTDP1 | |
| SCHEMBL3519518 | 0.78 | ALDH1A1 (1.00) | ALDH1A1GAAKDM4EMAPTTDP1 | |
| Hydrochloric Acid SCHEMBL8843605 | 0.78 | ALDH1A1 (0.93) | ALDH1A1GAAKDM4EMAPTTDP1 | |
| SCHEMBL5573167 | 0.78 | ALDH1A1 (1.00) | ALDH1A1GAAKDM4EMAPTTDP1 | |
| SCHEMBL7078279 | 0.77 | ALDH1A1 (0.59) | ALDH1A1GAAKDM4EMAPTTDP1 | |
| SCHEMBL9733660 | 0.77 | ALDH1A1 (0.79) | ALDH1A1GAAKDM4EMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1727793-B1 | SUBSTITUTED AZETIDINE COMPOUNDS AS CYCLOOXYGENASE-1 - CYCLOOXYGENASE-2 INHIBITORS, AND THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE LABOR DR (ES) | 2008-04-09 | — | — | EP | claimed |
| US-20070093469-A1 | Substituted azetidine compounds as cyclooxygenase-1-cyclooxygenase-2 inhibitors, and their preparation and use as medicaments | LABORATORIOS DEL DR. ESTEVE S.A (ES) | 2007-04-26 | — | — | US | claimed |
| EP-1727793-A1 | SUBSTITUTED AZETIDINE COMPOUNDS AS CYCLOOXYGENASE-1 - CYCLOOXYGENASE-2 INHIBITORS, AND THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2006-12-06 | — | — | EP | claimed |
| WO-2005077896-A1 | SUBSTITUTED AZETIDINE COMPOUNDS AS CYCLOOXYGENASE-1-CYCLOOXYGENASE-2 INHIBITORS, AND THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2005-08-25 | — | — | WO | claimed |
| US-20050182041-A1 | Substituted Azetidine compounds, their preparation and use as medicaments | LABORATOIOS DE DR. ESTEVE S.A. (ES) | 2005-08-18 | — | — | US | claimed |
| EP-1727793-B1 | SUBSTITUTED AZETIDINE COMPOUNDS AS CYCLOOXYGENASE-1 - CYCLOOXYGENASE-2 INHIBITORS, AND THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE LABOR DR (ES) | 2008-04-09 | — | — | EP | disclosed |
| EP-1727793-B1 | SUBSTITUTED AZETIDINE COMPOUNDS AS CYCLOOXYGENASE-1 - CYCLOOXYGENASE-2 INHIBITORS, AND THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE LABOR DR (ES) | 2008-04-09 | — | — | EP | disclosed |
| US-7232812-B2 | Substituted azetidine compounds, their preparation and use as medicaments | LABORATORIOS DE DR. ESTEVE S.A. (ES) | 2007-06-19 | — | — | US | disclosed |
| US-7232812-B2 | Substituted azetidine compounds, their preparation and use as medicaments | LABORATORIOS DE DR. ESTEVE S.A. (ES) | 2007-06-19 | — | — | US | disclosed |
| US-7232812-B2 | Substituted azetidine compounds, their preparation and use as medicaments | LABORATORIOS DE DR. ESTEVE S.A. (ES) | 2007-06-19 | — | — | US | disclosed |
| US-20070093469-A1 | Substituted azetidine compounds as cyclooxygenase-1-cyclooxygenase-2 inhibitors, and their preparation and use as medicaments | LABORATORIOS DEL DR. ESTEVE S.A (ES) | 2007-04-26 | — | — | US | disclosed |
| US-20070093469-A1 | Substituted azetidine compounds as cyclooxygenase-1-cyclooxygenase-2 inhibitors, and their preparation and use as medicaments | LABORATORIOS DEL DR. ESTEVE S.A (ES) | 2007-04-26 | — | — | US | disclosed |
| US-20070093469-A1 | Substituted azetidine compounds as cyclooxygenase-1-cyclooxygenase-2 inhibitors, and their preparation and use as medicaments | LABORATORIOS DEL DR. ESTEVE S.A (ES) | 2007-04-26 | — | — | US | disclosed |
| EP-1727793-A1 | SUBSTITUTED AZETIDINE COMPOUNDS AS CYCLOOXYGENASE-1 - CYCLOOXYGENASE-2 INHIBITORS, AND THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2006-12-06 | — | — | EP | disclosed |
| WO-2005077896-A1 | SUBSTITUTED AZETIDINE COMPOUNDS AS CYCLOOXYGENASE-1-CYCLOOXYGENASE-2 INHIBITORS, AND THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2005-08-25 | — | — | WO | disclosed |
| US-20050182041-A1 | Substituted Azetidine compounds, their preparation and use as medicaments | LABORATOIOS DE DR. ESTEVE S.A. (ES) | 2005-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093469-A1 | Substituted azetidine compounds as cyclooxygenase-1-cyclooxygenase-2 inhibitors, and their preparation and use as medicaments | PTGS1, PTGS2, PTGES2 | ALDH1A1 52/4885GAA 614/4885KDM4E 1674/4885 |
| US-20050182041-A1 | Substituted Azetidine compounds, their preparation and use as medicaments | AZI2, NISCH, QDPR | ALDH1A1 335/4885GAA 24/4885KDM4E 1156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.