⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6607326 | 1.00 | CA2 (0.32) | — | |
| SCHEMBL6055461 | 0.97 | CA2 (0.31) | — | |
| SCHEMBL9647392 | 0.97 | — | — | |
| SCHEMBL1943297 | 0.83 | — | — | |
| SCHEMBL2020071 | 0.82 | CA2 (0.30) | — | |
| SCHEMBL4599324 | 0.82 | CA2 (0.30) | — | |
| SCHEMBL1942581 | 0.80 | — | — | |
| SCHEMBL372657 | 0.80 | — | — | |
| SCHEMBL4598997 | 0.79 | — | — | |
| SCHEMBL217913 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 93 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110248939-B | Tyrosine amide derivatives as RHO-kinase inhibitors | 奇斯药制品公司 | 2022-05-17 | — | — | CN | claimed |
| US-10954236-B2 | Tyrosine amide derivatives as Rho-Kinase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2021-03-23 | — | — | US | claimed |
| EP-3573987-B1 | TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARM SPA (IT) | 2021-03-10 | — | — | EP | claimed |
| US-20200079774-A1 | TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2020-03-12 | — | — | US | claimed |
| CN-110248939-A | tyrosine amide derivatives as RHO-kinase inhibitors | 奇斯药制品公司 | 2019-09-17 | — | — | CN | claimed |
| US-20180215758-A1 | TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-08-02 | — | — | US | claimed |
| WO-2018138293-A1 | TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-08-02 | — | — | WO | claimed |
| US-5321057-A | Ammonium polyphosphate microencapsulated with aminoplastic resins | MINISTERO DELL'UNIVERSITA' E DELLA RICERCA SCIENTIFICA E TECNOLOGICA (IT) | 1994-06-14 | — | — | US | claimed |
| CN-115702148-A | Process for the manufacture of alkylamide thiazoles | 帝斯曼知识产权资产管理有限公司 | 2023-02-14 | — | — | CN | disclosed |
| CN-110248939-B | Tyrosine amide derivatives as RHO-kinase inhibitors | 奇斯药制品公司 | 2022-05-17 | — | — | CN | disclosed |
| US-10954236-B2 | Tyrosine amide derivatives as Rho-Kinase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2021-03-23 | — | — | US | disclosed |
| EP-3573987-B1 | TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARM SPA (IT) | 2021-03-10 | — | — | EP | disclosed |
| US-20200079774-A1 | TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2020-03-12 | — | — | US | disclosed |
| CN-110248939-A | tyrosine amide derivatives as RHO-kinase inhibitors | 奇斯药制品公司 | 2019-09-17 | — | — | CN | disclosed |
| EP-0453871-A1 | Salts of triazine derivatives with oxygenated acids of phosphorus | MINISTERO DELL' UNIVERSITA' E DELLA RICERCA SCIENTIFICA E TECNOLOGICA (IT) | 1991-10-30 | — | — | EP | disclosed |
| EP-0451807-A2 | Self-extinguishing polymeric compositions | MINISTERO DELL' UNIVERSITA' E DELLA RICERCA SCIENTIFICA E TECNOLOGICA (IT) | 1991-10-16 | — | — | EP | disclosed |
| EP-0415371-A2 | Self-extinguishing polymeric compositions | MINISTERO DELL' UNIVERSITA' E DELLA RICERCA SCIENTIFICA E TECNOLOGICA (IT) | 1991-03-06 | — | — | EP | disclosed |
| EP-0406810-A1 | Self-extinguishing polymeric compositions | MINISTERO DELL' UNIVERSITA' E DELLA RICERCA SCIENTIFICA E TECNOLOGICA (IT) | 1991-01-09 | — | — | EP | disclosed |
| US-4076642-A | Novel monoepoxy compounds as acid scavengers in functional fluids | MONSANTO COMPANY (US) | 1978-02-28 | — | — | US | disclosed |
| US-4076642-A | Novel monoepoxy compounds as acid scavengers in functional fluids | MONSANTO COMPANY (US) | 1978-02-28 | — | — | US | disclosed |