SCHEMBL4599300

SCHEMBL4599300

Brc1cc[c]c(NCCc2ccccc2)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCNC P24863 1/20 0.45
CDK8 P49336 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.44
RAB9A P51151 4/20 0.42
NPC1 O15118 3/20 0.42
TAAR1 Q96RJ0 2/20 0.40
POLB P06746 1/20 0.40
SMN1; SMN2 Q16637 3/20 0.39
CYP1A2 P05177 2/20 0.39
CYP3A4 P08684 2/20 0.39
CYP2D6 P10635 2/20 0.39
CYP2C9 P11712 2/20 0.39
CYP2C19 P33261 2/20 0.39
ALDH1A1 P00352 2/20 0.39
ATM Q13315 1/20 0.39
KDM1A O60341 1/20 0.39
LMNA P02545 1/20 0.39
HTR1A P08908 1/20 0.39
ADRA2A P08913 1/20 0.39
CYP2C8 P10632 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4599182 0.83 HTT (0.43) SMN1; SMN2LMNAKMT2AAPP
SCHEMBL4599961 0.81 L3MBTL1 (0.49) L3MBTL1RAB9ANPC1TAAR1SMN1; SMN2
SCHEMBL4599749 0.81 CCNC (0.45) CCNCCDK8L3MBTL1RAB9ANPC1
SCHEMBL2454621 0.78 L3MBTL1 (0.52) L3MBTL1RAB9ANPC1TAAR1SMN1; SMN2
SCHEMBL4598481 0.76 BCHE (0.52) MAOBMEN1KMT2A
SCHEMBL4600195 0.75 POLB (0.56) CCNCCDK8RAB9ANPC1TAAR1
SCHEMBL10388319 0.73 NPC1 (0.62) L3MBTL1RAB9ANPC1TAAR1SMN1; SMN2
SCHEMBL4598926 0.72 GABRA1 (0.34)
SCHEMBL3460165 0.71 L3MBTL1 (0.63) CCNCCDK8L3MBTL1RAB9ANPC1
SCHEMBL4611281 0.71 FAAH (0.40) L3MBTL1POLBSMN1; SMN2CYP3A4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1910320-A2 INTERMEDIATE COMPOUND FOR SYNTHESIZING PHARMACEUTICAL AGENT AND PRODUCTION METHOD THEREOF Mitsubishi Tanabe Pharma Corporation (JP) 2008-04-16 EP claimed
WO-2007011065-A2 INTERMEDIATE COMPOUND FOR SYNTHESIZING PHARMACEUTICAL AGENT AND PRODUCTION METHOD THEREOF MITSUBISHI TANABE PHARMA CORPORATION (JP) 2007-01-25 WO claimed
EP-1910320-A2 INTERMEDIATE COMPOUND FOR SYNTHESIZING PHARMACEUTICAL AGENT AND PRODUCTION METHOD THEREOF Mitsubishi Tanabe Pharma Corporation (JP) 2008-04-16 EP disclosed
WO-2007011065-A2 INTERMEDIATE COMPOUND FOR SYNTHESIZING PHARMACEUTICAL AGENT AND PRODUCTION METHOD THEREOF MITSUBISHI TANABE PHARMA CORPORATION (JP) 2007-01-25 WO disclosed