Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ATP4A | P20648 | 3/20 | 0.34 |
| ▸ | ATP4B | P51164 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | JAK1 | P23458 | 2/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.30 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4600457 | 1.00 | ALDH1A1 (0.36) | ALDH1A1KDM4ECYP3A4CYP2C9CYP1A2 | |
| SCHEMBL4600269 | 0.93 | ALDH1A1 (0.35) | ALDH1A1KDM4EATP4AATP4BPPARG | |
| SCHEMBL4600263 | 0.93 | ALDH1A1 (0.35) | ALDH1A1KDM4EATP4AATP4BPPARG | |
| SCHEMBL4600463 | 0.91 | ALDH1A1 (0.35) | ALDH1A1KDM4ECYP3A4CYP2C9CYP1A2 | |
| SCHEMBL4599488 | 0.91 | MAPT (0.35) | ALDH1A1KDM4ECYP1A2CYP2C19ATP4A | |
| SCHEMBL4600103 | 0.91 | ALDH1A1 (0.34) | ALDH1A1KDM4EATP4AATP4BPPARG | |
| SCHEMBL4599481 | 0.91 | MAPT (0.35) | ALDH1A1KDM4ECYP1A2CYP2C19ATP4A | |
| SCHEMBL4600936 | 0.90 | JAK2 (0.34) | ALDH1A1KDM4EATP4AATP4BJAK2 | |
| SCHEMBL4611844 | 0.88 | ALDH1A1 (0.36) | ALDH1A1KDM4ECYP3A4CYP2C9CYP1A2 | |
| SCHEMBL4611846 | 0.88 | ALDH1A1 (0.36) | ALDH1A1KDM4ECYP3A4CYP2C9CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718648-B1 | TRICYCLIC IMIDAZOPYRIDINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | NYCOMED GMBH (DE) | 2008-04-23 | — | — | EP | disclosed |
| EP-1718648-A1 | TRICYCLIC IMIDAZOPYRIDINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | Altana Pharma AG (DE) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005077949-A1 | TRICYCLIC IMIDAZOPYRIDINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | ALTANA PHARMA AG (DE) | 2005-08-25 | — | — | WO | disclosed |