Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4611846 | 1.00 | ALDH1A1 (0.36) | ALDH1A1KMT2ATSHRMEN1LMNA | |
| SCHEMBL4600263 | 0.89 | ALDH1A1 (0.35) | ALDH1A1KMT2ATSHRMEN1LMNA | |
| SCHEMBL4600269 | 0.89 | ALDH1A1 (0.35) | ALDH1A1KMT2ATSHRMEN1LMNA | |
| SCHEMBL4600465 | 0.88 | ALDH1A1 (0.36) | ALDH1A1KDM4ECYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4600457 | 0.88 | ALDH1A1 (0.36) | ALDH1A1KDM4ECYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4599481 | 0.87 | MAPT (0.35) | ALDH1A1LMNAKDM4EHPGDSMN1; SMN2 | |
| SCHEMBL4600103 | 0.87 | ALDH1A1 (0.34) | ALDH1A1KDM4ERAB9AATP4AATP4B | |
| SCHEMBL4599488 | 0.87 | MAPT (0.35) | ALDH1A1LMNAKDM4EHPGDSMN1; SMN2 | |
| SCHEMBL4600936 | 0.86 | JAK2 (0.34) | ALDH1A1LMNAKDM4EPOLBATP4A | |
| Hydrochloric Acid SCHEMBL4600901 | 0.82 | ALDH1A1 (0.40) | ALDH1A1KMT2ATSHRMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718648-B1 | TRICYCLIC IMIDAZOPYRIDINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | NYCOMED GMBH (DE) | 2008-04-23 | — | — | EP | disclosed |
| EP-1718648-A1 | TRICYCLIC IMIDAZOPYRIDINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | Altana Pharma AG (DE) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005077949-A1 | TRICYCLIC IMIDAZOPYRIDINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | ALTANA PHARMA AG (DE) | 2005-08-25 | — | — | WO | disclosed |