Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | ATP4A | P20648 | 2/20 | 0.33 |
| ▸ | ATP4B | P51164 | 2/20 | 0.33 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4599488 | 1.00 | MAPT (0.35) | MAPTL3MBTL1ALDH1A1KDM4EATP4A | |
| SCHEMBL4600269 | 0.92 | ALDH1A1 (0.35) | L3MBTL1ALDH1A1KDM4EATP4AATP4B | |
| SCHEMBL4600263 | 0.92 | ALDH1A1 (0.35) | L3MBTL1ALDH1A1KDM4EATP4AATP4B | |
| SCHEMBL4599487 | 0.91 | L3MBTL1 (0.33) | MAPTL3MBTL1ALDH1A1KDM4EATP4A | |
| SCHEMBL4600936 | 0.91 | JAK2 (0.34) | MAPTALDH1A1KDM4EATP4AATP4B | |
| SCHEMBL4600465 | 0.91 | ALDH1A1 (0.36) | ALDH1A1KDM4EATP4AATP4BCPB2 | |
| SCHEMBL4600457 | 0.91 | ALDH1A1 (0.36) | ALDH1A1KDM4EATP4AATP4BCPB2 | |
| SCHEMBL4600103 | 0.90 | ALDH1A1 (0.34) | ALDH1A1KDM4EATP4AATP4BPPARG | |
| SCHEMBL4611846 | 0.87 | ALDH1A1 (0.36) | L3MBTL1ALDH1A1KDM4EATP4AATP4B | |
| SCHEMBL4611844 | 0.87 | ALDH1A1 (0.36) | L3MBTL1ALDH1A1KDM4EATP4AATP4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718648-B1 | TRICYCLIC IMIDAZOPYRIDINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | NYCOMED GMBH (DE) | 2008-04-23 | — | — | EP | disclosed |
| EP-1718648-A1 | TRICYCLIC IMIDAZOPYRIDINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | Altana Pharma AG (DE) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005077949-A1 | TRICYCLIC IMIDAZOPYRIDINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | ALTANA PHARMA AG (DE) | 2005-08-25 | — | — | WO | disclosed |