Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR2E3 | Q9Y5X4 | 6/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 6/20 | 0.58 |
| ▸ | PRSS12 | P56730 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4600057 | 0.88 | CHEK2 (0.58) | NR2E3CHEK2KDM4EMAPTALDH1A1 | |
| SCHEMBL1136458 | 0.85 | CHEK2 (0.52) | NR2E3CHEK2PRSS12KDM4EMAPT | |
| SCHEMBL8769518 | 0.81 | HPSE (0.73) | NR2E3CHEK2PRSS12KDM4EMAPT | |
| SCHEMBL19174176 | 0.80 | MMP2 (0.74) | NR2E3CHEK2KDM4EMAPTALDH1A1 | |
| SCHEMBL8613521 | 0.80 | CHEK2 (0.79) | CHEK2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL8767573 | 0.80 | MAPT (0.67) | NR2E3CHEK2KDM4EMAPTALDH1A1 | |
| SCHEMBL3929679 | 0.80 | CHEK2 (0.83) | CHEK2PRSS12KDM4EMAPTHPSE | |
| SCHEMBL14381675 | 0.80 | PRSS12 (0.67) | NR2E3CHEK2PRSS12KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL19149751 | 0.79 | MMP2 (0.73) | NR2E3CHEK2KDM4EMAPTALDH1A1 | |
| SCHEMBL3927839 | 0.78 | CHEK2 (0.84) | CHEK2PRSS12HPSEMEN1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919910-A1 | AZABENZIMIDAZOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS ANTI-CANCER AGENTS | F. Hoffmann-la Roche AG (CH) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007017143-A1 | AZABENZIMIDAZOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS ANTI-CANCER AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-15 | — | — | WO | disclosed |