Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12404098 | 0.77 | ALDH1A1 (0.55) | MEN1KMT2ASMN1; SMN2CYP2C9CYP2C19 | |
| SCHEMBL13929453 | 0.77 | ALDH1A1 (0.55) | MEN1KMT2ASMN1; SMN2CYP2C9CYP2C19 | |
| Bicarbonate SCHEMBL2854194 | 0.76 | GBA1 (0.52) | MEN1KMT2ACYP2C9CYP2C19MAPK14 | |
| SCHEMBL6794966 | 0.75 | LOXL2 (0.50) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL31352725 | 0.75 | LOXL2 (0.58) | KDM4EMEN1KMT2AMAPT | |
| SCHEMBL5675291 | 0.73 | GBA1 (0.57) | ALDH1A1 | |
| SCHEMBL757429 | 0.73 | LOXL2 (0.62) | KDM4EMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Acrylic Acid Methyl Ester SCHEMBL28073382 | 0.73 | MEN1 (0.45) | MEN1KMT2ASMN1; SMN2CYP2C9CYP2C19 | |
| SCHEMBL21494357 | 0.72 | ALDH1A1 (0.49) | MEN1KMT2ASMN1; SMN2CYP2C9CYP2C19 | |
| SCHEMBL6963348 | 0.72 | LOXL2 (0.54) | MEN1KMT2ASMN1; SMN2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910358-A2 | HETEROCYCLIC JANUS KINASE 3 INHIBITORS | Astellas Pharma Inc. (JP) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007007919-A2 | HETEROCYCLIC JANUS KINASE 3 INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2007-01-18 | — | — | WO | disclosed |