Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | SNCA | P37840 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4585665 | 0.81 | HTR2C (0.48) | HTR2CKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11095741 | 0.79 | HTR2C (0.50) | HTR2CKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9508351 | 0.79 | ALDH1A1 (0.49) | HTR2CKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL12914319 | 0.78 | HTR2C (0.46) | HTR2CKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL30987375 | 0.78 | PTPN1 (0.50) | HTR2CKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL28745186 | 0.78 | PTPN1 (0.50) | HTR2CKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL1538345 | 0.76 | HTR2C (0.44) | HTR2CKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL10988411 | 0.76 | HTR2C (0.47) | HTR2CKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL251035 | 0.74 | KDM4E (0.53) | HTR2CKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7038054 | 0.73 | ENPP1 (0.43) | HTR2CKDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912959-A2 | 5-SUBSTITUTED THIAZOL-2-YL AMINO COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-04-23 | — | — | EP | claimed |
| WO-2007016228-A2 | 5-SUBSTITUTED THIAZOL-2-YL AMINO COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2007-02-08 | — | — | WO | claimed |