Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.58 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CETP | P11597 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.45 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4615147 | 0.81 | ALDH1A1 (0.58) | GAAKMT2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4604019 | 0.80 | SMN1; SMN2 (0.47) | HDAC1HDAC2GAAKMT2AALDH1A1 | |
| SCHEMBL1749706 | 0.79 | KMT2A (0.57) | P2RX7GAAKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL31047113 | 0.79 | ALDH1A1 (0.51) | HDAC1KMT2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6825065 | 0.76 | P2RX7 (0.72) | HDAC1HDAC2P2RX7GAAKMT2A | |
| SCHEMBL5803069 | 0.76 | P2RX7 (0.76) | HDAC1HDAC2P2RX7GAAALDH1A1 | |
| SCHEMBL3926172 | 0.74 | ALDH1A1 (0.57) | HDAC1HDAC2KMT2AALDH1A1HPGD | |
| SCHEMBL13833695 | 0.74 | HDAC1 (1.00) | HDAC1HDAC2HDAC3 | |
| SCHEMBL2805441 | 0.73 | TTR (0.53) | GAAKMT2AKDM4E | |
| SCHEMBL272092 | 0.73 | TTR (0.56) | GAAKMT2AALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940786-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | Arrow Therapeutics Limited (GB) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007031791-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2007-03-22 | — | — | WO | disclosed |