Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 3/20 | 0.40 |
| ▸ | LIPE | Q05469 | 3/20 | 0.39 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4600789 | 0.88 | HPGD (0.48) | PPARGLIPELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL4601003 | 0.83 | HPGD (0.48) | PPARGLIPELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL4602781 | 0.81 | EGFR (0.45) | EGFRITKKDM4EPOLBALDH1A1 | |
| SCHEMBL4602178 | 0.81 | EGFR (0.43) | EGFRITKKDM4EPOLBLMNA | |
| SCHEMBL4600672 | 0.80 | FABP3 (0.54) | EGFRSGMS2KDM4EPOLBLMNA | |
| SCHEMBL4602102 | 0.79 | HPGD (0.49) | PPARGLIPEKDM4EPOLBLMNA | |
| Water SCHEMBL4601371 | 0.78 | HPGD (0.48) | PPARGLIPEKDM4EPOLBLMNA | |
| SCHEMBL4601218 | 0.77 | MRGPRX4 (0.46) | EGFRPPARGKDM4EALDH1A1 | |
| SCHEMBL4601556 | 0.76 | HPGD (0.47) | PPARGLIPEKDM4EPOLBLMNA | |
| SCHEMBL4614803 | 0.76 | EGFR (0.42) | EGFRITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912645-A2 | THERAPEUTIC AGENT FOR DIABETES | Takeda Pharmaceutical Company Limited (JP) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007018314-A2 | THERAPEUTIC AGENT FOR DIABETES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-15 | — | — | WO | disclosed |