Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.43 |
| ▸ | ITK | Q08881 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | LYN | P07948 | 1/20 | 0.33 |
| ▸ | TEC | P42680 | 1/20 | 0.33 |
| ▸ | TXK | P42681 | 1/20 | 0.33 |
| ▸ | BMX | P51813 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | CD69 | Q07108 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4602781 | 0.88 | EGFR (0.45) | EGFRITKKDM4EKMT2ABTK | |
| SCHEMBL4602334 | 0.82 | EGFR (0.37) | EGFRITKKDM4EKMT2AAAK1 | |
| SCHEMBL4601490 | 0.82 | EGFR (0.42) | EGFRITKBTKJAK2LYN | |
| SCHEMBL4601414 | 0.81 | EGFR (0.44) | EGFRITKKDM4EALDH1A1POLB | |
| SCHEMBL4614803 | 0.79 | EGFR (0.42) | EGFRITKKDR | |
| SCHEMBL4600789 | 0.77 | HPGD (0.48) | ALDH1A1LMNA | |
| SCHEMBL4600628 | 0.75 | EGFR (0.47) | EGFRITKKDM4EKMT2ABTK | |
| SCHEMBL4601601 | 0.74 | EGFR (0.47) | EGFRITKKDM4EKMT2AALDH1A1 | |
| SCHEMBL4600130 | 0.73 | EGFR (0.47) | EGFRITKKDM4EKMT2AMEN1 | |
| SCHEMBL4602183 | 0.73 | EGFR (0.47) | EGFRKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912645-A2 | THERAPEUTIC AGENT FOR DIABETES | Takeda Pharmaceutical Company Limited (JP) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007018314-A2 | THERAPEUTIC AGENT FOR DIABETES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-15 | — | — | WO | disclosed |