Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 5/20 | 0.57 |
| ▸ | AKT2 | P31751 | 3/20 | 0.56 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.56 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.56 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.56 |
| ▸ | PLCG2 | P16885 | 2/20 | 0.52 |
| ▸ | GAB1 | Q13480 | 1/20 | 0.52 |
| ▸ | GPR55 | Q9Y2T6 | 3/20 | 0.52 |
| ▸ | NR5A2 | O00482 | 1/20 | 0.51 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.51 |
| ▸ | ITPR3 | Q14573 | 1/20 | 0.50 |
| ▸ | ITPR1 | Q14643 | 1/20 | 0.50 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.48 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4565034 | 0.88 | AKT1 (0.64) | AKT1AKT2AKT3PIK3R1PIK3CA | |
| SCHEMBL11131399 | 0.85 | LPAR1 (0.56) | AKT1AKT2AKT3PIK3R1PIK3CA | |
| SCHEMBL749657 | 0.83 | AKT1 (0.70) | AKT1AKT2AKT3PIK3R1PIK3CA | |
| SCHEMBL1082266 | 0.83 | AKT1 (0.70) | AKT1AKT2AKT3PIK3R1PIK3CA | |
| SCHEMBL4601846 | 0.82 | AKT1 (0.54) | AKT1AKT2AKT3PIK3R1PIK3CA | |
| SCHEMBL13111076 | 0.78 | SMPD1 (0.79) | AKT1AKT2AKT3PIK3R1PIK3CA | |
| SCHEMBL13111188 | 0.78 | SMPD1 (0.79) | AKT1AKT2AKT3PIK3R1PIK3CA | |
| SCHEMBL3261983 | 0.78 | LPAR3 (0.74) | LPAR1LPAR3 | |
| SCHEMBL4435249 | 0.78 | LPAR3 (0.74) | LPAR1LPAR3 | |
| SCHEMBL1534300 | 0.78 | LPAR3 (0.74) | LPAR1LPAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885385-A2 | PHOSPHATIDYLINOSITOL COMBINATION COMPOSITION AND 3'-PHOSPHORYLATED LYSOPHOSPHATIDYLINOSITOLS IN THE TREATMENT OF CANCER AND AUTOIMMUNE DISEASES | THURNHER, Martin Andreas (AT) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006128679-A2 | PHOSPHATIDYLINOSITOL COMPOSITION AND 3'-PHOSPHORYLATED LYSOPHOSPHATIDYLINOSITOLS IN THE TREATMENT OF CANCER AND AUTOIMMUNE DISEASES | THURNHER MARTIN ANDREAS (AT) | 2006-12-07 | — | — | WO | disclosed |