Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.61 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.55 |
| ▸ | GRM5 | P41594 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13877018 | 0.83 | MAPK14 (0.81) | MAPK14 | |
| SCHEMBL7005456 | 0.78 | MAPK14 (0.74) | MAPK14 | |
| SCHEMBL17961915 | 0.77 | ALDH1A1 (0.56) | MAPK14HSD17B10 | |
| SCHEMBL11961891 | 0.77 | ALDH1A1 (0.56) | MAPK14HSD17B10 | |
| SCHEMBL30966016 | 0.77 | MAOA (0.53) | MAPK14GRM5APP | |
| SCHEMBL15765661 | 0.77 | CASP1 (0.53) | MAPK14MKNK1GRM5CASP1CASP7 | |
| SCHEMBL2316384 | 0.76 | MAPK14 (1.00) | MAPK14 | |
| SCHEMBL15190881 | 0.76 | BAZ2B (0.60) | MAPK14MKNK1GRM5CASP1CASP7 | |
| SCHEMBL13769497 | 0.76 | MAPK14 (0.66) | MAPK14 | |
| SCHEMBL7168804 | 0.76 | HSD17B10 (0.54) | MAPK14APPHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910338-A2 | HETEROTETRACYCLIC COMPOUNDS AS TPO MIMETICS | IRM, LLC (BM) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007009120-A2 | HETEROTETRACYCLIC COMPOUNDS AS TPO MIMETICS | IRM LLC (BM) | 2007-01-18 | — | — | WO | disclosed |