Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | ESRRB | O95718 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESRRG | P62508 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4602100 | 1.00 | HRH3 (0.49) | HRH3CHRM4FDFT1S1PR1S1PR5 | |
| SCHEMBL8218213 | 0.78 | FDFT1 (0.47) | CHRM4FDFT1S1PR5BCHENPC1 | |
| SCHEMBL8218218 | 0.78 | FDFT1 (0.47) | CHRM4FDFT1S1PR5BCHENPC1 | |
| SCHEMBL1941467 | 0.78 | FDFT1 (0.47) | CHRM4FDFT1S1PR5BCHENPC1 | |
| SCHEMBL6622776 | 0.77 | FDFT1 (0.44) | HRH3CHRM4FDFT1BCHENPC1 | |
| SCHEMBL4083380 | 0.76 | FDFT1 (0.46) | HRH3CHRM4FDFT1BCHEPRMT5 | |
| SCHEMBL4083377 | 0.76 | FDFT1 (0.46) | HRH3CHRM4FDFT1BCHEPRMT5 | |
| SCHEMBL2682972 | 0.76 | FDFT1 (0.46) | HRH3CHRM4FDFT1BCHEPRMT5 | |
| SCHEMBL8214501 | 0.76 | NPC1 (0.56) | HRH3S1PR1S1PR3FFAR1NPC1 | |
| SCHEMBL5128246 | 0.76 | HRH3 (0.60) | HRH3CHRM4S1PR1S1PR5PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979819-B1 | Process for the production of substituted 3-hydroxypiperidines | SPEEDEL PHARMA AG (CH) | 2008-04-23 | — | — | EP | claimed |
| EP-0979824-B1 | Process for the preparation of substituted piperidine-epoxides | HOFFMANN LA ROCHE (CH) | 2004-10-06 | — | — | EP | claimed |
| EP-0979824-A1 | Process for the preparation of substituted piperidine-epoxides | F. HOFFMANN-LA ROCHE AG (CH) | 2000-02-16 | — | — | EP | claimed |
| EP-0979819-A1 | Process for the production of substituted 3-hydroxypiperidines | F. HOFFMANN-LA ROCHE AG (CH) | 2000-02-16 | — | — | EP | claimed |
| EP-0979819-B1 | Process for the production of substituted 3-hydroxypiperidines | SPEEDEL PHARMA AG (CH) | 2008-04-23 | — | — | EP | disclosed |
| EP-0979824-B1 | Process for the preparation of substituted piperidine-epoxides | HOFFMANN LA ROCHE (CH) | 2004-10-06 | — | — | EP | disclosed |
| CN-1161335-C | Method for preparing substituted piperidine | - | 2004-08-11 | — | — | CN | disclosed |
| CN-1111534-C | Method for preparing substituted piperidine-epoxide | HOFFMANN LA ROCHE (CH) | 2003-06-18 | — | — | CN | disclosed |
| US-6274735-B1 | RENIN INHIBITORS | HOFFMANN-LA ROCHE INC. | 2001-08-14 | — | — | US | disclosed |
| US-6268499-B1 | USEFUL AS RENIN INHIBITORS | HOFFMAN-LA ROCHE INC. | 2001-07-31 | — | — | US | disclosed |
| WO-2000063173-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED PIPERIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-10-26 | — | — | WO | disclosed |
| CN-1245800-A | Method for preparing substituted piperidine | HOFFMANN LA ROCHE (CH) | 2000-03-01 | — | — | CN | disclosed |
| CN-1245805-A | Method for preparing substituted piperidine-epoxide | HOFFMANN LA ROCHE (CH) | 2000-03-01 | — | — | CN | disclosed |
| EP-0979824-A1 | Process for the preparation of substituted piperidine-epoxides | F. HOFFMANN-LA ROCHE AG (CH) | 2000-02-16 | — | — | EP | disclosed |
| EP-0979819-A1 | Process for the production of substituted 3-hydroxypiperidines | F. HOFFMANN-LA ROCHE AG (CH) | 2000-02-16 | — | — | EP | disclosed |