Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 7/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | LSS | P48449 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4602334 | 0.81 | EGFR (0.37) | KDM4ELMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3205613 | 0.79 | PPARG (0.47) | KDM4ELMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3205624 | 0.79 | PPARG (0.47) | KDM4ELMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4602178 | 0.71 | EGFR (0.43) | KDM4ELMNAKMT2AAAK1ALDH1A1 | |
| SCHEMBL1816280 | 0.70 | TSHR (0.40) | KDM4ELMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL27009298 | 0.68 | ALDH1A1 (0.54) | KDM4ELMNAKMT2AALDH1A1 | |
| SCHEMBL1505065 | 0.67 | CNR2 (0.48) | KMT2AHPGDCNR2ALDH1A1 | |
| SCHEMBL16510360 | 0.67 | KDM4E (0.49) | KDM4ETDP1HTTHPGD | |
| SCHEMBL3199078 | 0.67 | PPARG (0.49) | KDM4EKMT2APPARGCHEK2ALDH1A1 | |
| SCHEMBL3199101 | 0.67 | PPARG (0.49) | KDM4EKMT2APPARGCHEK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912645-A2 | THERAPEUTIC AGENT FOR DIABETES | Takeda Pharmaceutical Company Limited (JP) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007018314-A2 | THERAPEUTIC AGENT FOR DIABETES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-15 | — | — | WO | disclosed |