Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 4/20 | 0.35 |
| ▸ | PPARG | P37231 | 3/20 | 0.34 |
| ▸ | ITK | Q08881 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | LYN | P07948 | 1/20 | 0.34 |
| ▸ | TEC | P42680 | 1/20 | 0.34 |
| ▸ | TXK | P42681 | 1/20 | 0.34 |
| ▸ | BMX | P51813 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | CD69 | Q07108 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4602178 | 0.82 | EGFR (0.43) | EGFRLMNABTKITKJAK2 | |
| SCHEMBL4602335 | 0.81 | KDM4E (0.38) | LMNACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3205613 | 0.78 | PPARG (0.47) | LMNACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3205624 | 0.78 | PPARG (0.47) | LMNACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4631636 | 0.72 | PDE4B (0.43) | EGFR | |
| SCHEMBL12796997 | 0.71 | THRB (0.54) | EGFR | |
| SCHEMBL4632439 | 0.71 | PDE4D (0.42) | — | |
| SCHEMBL4602781 | 0.70 | EGFR (0.45) | EGFRBTKITKJAK2LYN | |
| SCHEMBL1816280 | 0.69 | TSHR (0.40) | LMNACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL19564418 | 0.68 | THRB (0.46) | EGFRCYP3A4BTKITKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912645-A2 | THERAPEUTIC AGENT FOR DIABETES | Takeda Pharmaceutical Company Limited (JP) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007018314-A2 | THERAPEUTIC AGENT FOR DIABETES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-15 | — | — | WO | disclosed |