Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.43 |
| ▸ | HRH1 | P35367 | 6/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4600790 | 0.93 | PPARG (0.40) | PPARGHRH1KCNH2PDE4DPDE4A | |
| SCHEMBL4600676 | 0.87 | PPARG (0.44) | PPARGRAB9AKDM4EMAPTNPC1 | |
| SCHEMBL4602137 | 0.84 | PPARG (0.41) | PPARGRAB9ANPC1GRM5 | |
| SCHEMBL4600582 | 0.81 | PPARG (0.60) | PPARGKDM4EMAPT | |
| SCHEMBL27716297 | 0.81 | PPARG (0.43) | PPARGPDE4D | |
| SCHEMBL4602971 | 0.79 | PPARG (0.41) | PPARG | |
| SCHEMBL4600892 | 0.76 | PPARG (0.75) | PPARG | |
| SCHEMBL27737202 | 0.75 | PPARG (0.43) | PPARGPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL27716255 | 0.74 | PPARG (0.44) | PPARGPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL4602019 | 0.74 | PPARG (0.45) | PPARGKCNH2PDE4DPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912645-A2 | THERAPEUTIC AGENT FOR DIABETES | Takeda Pharmaceutical Company Limited (JP) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007018314-A2 | THERAPEUTIC AGENT FOR DIABETES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-15 | — | — | WO | disclosed |