SCHEMBL4603362

SCHEMBL4603362

N#Cc1ccc(C(=O)c2sc3ccccc3c2OCc2ccc(I)cc2)cc1

nearest known ligand 0.43

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
SENP2 Q9HC62 17/20 0.43
SENP1 Q9P0U3 17/20 0.43
SENP5 Q96HI0 16/20 0.43
RAB9A P51151 1/20 0.41
SMPD1 P17405 1/20 0.41
USP2 O75604 1/20 0.41
RXRA P19793 1/20 0.40
RXRB P28702 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4602746 0.95 SENP2 (0.46) SENP2SENP1SENP5RAB9ASMPD1
SCHEMBL4604692 0.91 SENP2 (0.50) SENP2SENP1SENP5USP2
SCHEMBL4604678 0.91 SRD5A2 (0.46) SENP2SENP1SENP5RAB9AUSP2
SCHEMBL4604236 0.90 SENP2 (0.52) SENP2SENP1SENP5RAB9ASMPD1
SCHEMBL4603947 0.88 KMT2A (0.47) SENP2SENP1SENP5RAB9AUSP2
SCHEMBL4603558 0.87 SENP2 (0.55) SENP2SENP1SENP5RAB9A
SCHEMBL4603816 0.86 TSHR (0.41) SENP2SENP1SENP5RAB9AUSP2
SCHEMBL4604237 0.85 SENP2 (0.48) SENP2SENP1SENP5USP2
SCHEMBL4605388 0.85 SENP2 (0.51) SENP2SENP1SENP5SMPD1USP2
SCHEMBL4605230 0.85 SENP2 (0.51) SENP2SENP1SENP5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1685122-B1 BENZOFURANS AND BENZOTHIOPHENES MERCK PATENT GMBH (DE) 2008-07-09 EP claimed
US-7371774-B2 Benzofurans and benzothiophenes MERCK PATENT GMBH (DE) 2008-05-13 US claimed
US-20070066680-A1 Benzofurans and benzothiophenes MERCK PATENT GMBH (DE) 2007-03-22 US claimed
EP-1685122-B1 BENZOFURANS AND BENZOTHIOPHENES MERCK PATENT GMBH (DE) 2008-07-09 EP disclosed
EP-1685122-B1 BENZOFURANS AND BENZOTHIOPHENES MERCK PATENT GMBH (DE) 2008-07-09 EP disclosed
US-7371774-B2 Benzofurans and benzothiophenes MERCK PATENT GMBH (DE) 2008-05-13 US disclosed
US-7371774-B2 Benzofurans and benzothiophenes MERCK PATENT GMBH (DE) 2008-05-13 US disclosed
US-7371774-B2 Benzofurans and benzothiophenes MERCK PATENT GMBH (DE) 2008-05-13 US disclosed
US-20070066680-A1 Benzofurans and benzothiophenes MERCK PATENT GMBH (DE) 2007-03-22 US disclosed
US-20070066680-A1 Benzofurans and benzothiophenes MERCK PATENT GMBH (DE) 2007-03-22 US disclosed
US-20070066680-A1 Benzofurans and benzothiophenes MERCK PATENT GMBH (DE) 2007-03-22 US disclosed
EP-1685122-A1 BENZOFURANS AND BENZOTHIOPHENES MERCK PATENT GmbH (DE) 2006-08-02 EP disclosed
WO-2005054226-A1 BENZOFURANS AND BENZOTHIOPHENES MERCK PATENT GMBH (DE) 2005-06-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070066680-A1 Benzofurans and benzothiophenes INSR, GPR119, IGF1R SENP2 4103/4885SENP1 3205/4885SENP5 3478/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.