SCHEMBL4603391

SCHEMBL4603391

O=C(CCl)c1cccc(N(c2ccccc2)S(=O)(=O)c2ccccc2)c1

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.49
ALDH1A1 P00352 4/20 0.49
TRPA1 O75762 1/20 0.49
MAPK1 P28482 1/20 0.49
GSK3B P49841 1/20 0.49
HIF1A Q16665 1/20 0.49
PKM P14618 1/20 0.47
HDAC6 Q9UBN7 1/20 0.45
LMNA P02545 3/20 0.44
SMN1; SMN2 Q16637 2/20 0.41
HTT P42858 1/20 0.41
HSD11B1 P28845 4/20 0.41
TP53 P04637 1/20 0.40
GLA P06280 1/20 0.40
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
PTPN1 P18031 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14185293 0.87 ALDH1A1 (0.50) ALDH1A1TRPA1MAPK1GSK3BHIF1A
SCHEMBL4603757 0.81 ESR1 (0.53) ESR1ALDH1A1MAPK1PKMLMNA
SCHEMBL812682 0.74 PKM (0.79) ESR1ALDH1A1PKMHDAC6LMNA
SCHEMBL6496987 0.72 KMT2A (0.53) ALDH1A1TRPA1MAPK1GSK3BHIF1A
SCHEMBL7250273 0.72 KMT2A (0.53) ALDH1A1TRPA1MAPK1GSK3BHIF1A
SCHEMBL7914241 0.71 CA1 (0.58) ALDH1A1TRPA1MAPK1GSK3BHIF1A
SCHEMBL8663009 0.71 PKM (0.58) ESR1ALDH1A1PKMLMNASMN1; SMN2
SCHEMBL4606413 0.70 HDAC2 (0.60) HDAC6MEN1KMT2A
SCHEMBL8973992 0.70 ALDH1A1 (0.57) ALDH1A1LMNASMN1; SMN2HTTHSD11B1
SCHEMBL11874771 0.70 ALDH1A1 (0.51) ALDH1A1TRPA1MAPK1GSK3BHIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1943229-A1 BENZIMIDAZOLE DERIVATIVES FOR USE AS BETA-3 RECEPTOR AGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2008-07-16 EP disclosed
EP-1943220-A2 NOVEL INDOLE-CONTAINING BETA AGONISTS, METHOD FOR PRODUCING THEM AND THEIR USE AS DRUGS Boehringer Ingelheim International GmbH (DE) 2008-07-16 EP disclosed
EP-1943227-A1 NOVEL BETA-AGONISTS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS Boehringer Ingelheim International GmbH (DE) 2008-07-16 EP disclosed
WO-2007048840-A1 NOVEL BETA-AGONISTS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2007-05-03 WO disclosed
WO-2007048842-A1 BENZIMIDAZOLE DERIVATIVES FOR USE AS BETA-3 RECEPTOR AGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2007-05-03 WO disclosed
WO-2007048841-A2 NOVEL INDOLE-CONTAINING BETA AGONISTS, METHOD FOR PRODUCING THEM AND THEIR USE AS DRUGS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2007-05-03 WO disclosed