Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 7/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | STAT3 | P40763 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4603728 | 0.93 | MAPT (0.56) | ALDH1A1MAPTSMN1; SMN2TGFBR1MEN1 | |
| SCHEMBL3572132 | 0.90 | MAPT (0.54) | ALDH1A1MAPTSMN1; SMN2TGFBR1MEN1 | |
| SCHEMBL13166091 | 0.90 | MAPT (0.54) | ALDH1A1MAPTSMN1; SMN2TGFBR1MEN1 | |
| SCHEMBL4603914 | 0.88 | TGFBR1 (0.58) | ALDH1A1MAPTSMN1; SMN2TGFBR1MEN1 | |
| SCHEMBL4605117 | 0.88 | ALDH1A1 (0.51) | ALDH1A1MAPTSMN1; SMN2TGFBR1MEN1 | |
| SCHEMBL4617947 | 0.88 | TGFBR1 (0.74) | ALDH1A1MAPTSMN1; SMN2TGFBR1MEN1 | |
| SCHEMBL4620251 | 0.87 | TGFBR1 (0.61) | ALDH1A1MAPTSMN1; SMN2TGFBR1MEN1 | |
| SCHEMBL4603323 | 0.85 | MEN1 (0.54) | ALDH1A1MAPTSMN1; SMN2TGFBR1MEN1 | |
| SCHEMBL4603144 | 0.84 | TGFBR1 (0.59) | ALDH1A1MAPTSMN1; SMN2TGFBR1MEN1 | |
| SCHEMBL13166079 | 0.83 | MAPT (0.53) | ALDH1A1MAPTSMN1; SMN2TGFBR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753512-B1 | TETRAHYDROPYRIDOTHIOPHENES | NYCOMED GMBH (DE) | 2008-07-09 | — | — | EP | claimed |