Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SSTR4 | P31391 | 7/20 | 0.40 |
| ▸ | SSTR1 | P30872 | 5/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 4/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | PREP | P48147 | 1/20 | 0.37 |
| ▸ | FAP | Q12884 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2201807 | 1.00 | POLB (0.42) | POLBCYP1A2CYP3A4CYP2C19SSTR4 | |
| SCHEMBL2547741 | 0.88 | ITGA4 (0.41) | SSTR4SSTR1GPR119GRM2 | |
| SCHEMBL8059551 | 0.84 | CYP1A2 (0.45) | POLBCYP1A2CYP3A4CYP2C19MEN1 | |
| SCHEMBL2200981 | 0.83 | ABCB1 (0.39) | SSTR4SSTR1GPR119GRM2SRC | |
| SCHEMBL2202034 | 0.83 | GPR119 (0.39) | SSTR4SSTR1GPR119GRM2MEN1 | |
| SCHEMBL4602385 | 0.83 | GPR119 (0.39) | SSTR4SSTR1GPR119GRM2MEN1 | |
| SCHEMBL8708455 | 0.82 | CYP3A4 (0.44) | POLBCYP1A2CYP3A4CYP2C19SRC | |
| SCHEMBL8708462 | 0.82 | CYP3A4 (0.44) | POLBCYP1A2CYP3A4CYP2C19SRC | |
| SCHEMBL29007980 | 0.81 | DPP4 (0.48) | SSTR4SSTR1MEN1KMT2ADPP4 | |
| SCHEMBL9068225 | 0.81 | PTGER1 (0.40) | POLBCYP1A2CYP3A4CYP2C19SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912994-A1 | ADENINE DERIVATIVES | Merck Patent GmbH (DE) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007017069-A1 | ADENINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-02-15 | — | — | WO | disclosed |