Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.49 |
| ▸ | MET | P08581 | 13/20 | 0.49 |
| ▸ | FLT1 | P17948 | 5/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3561621 | 0.85 | KDR (0.53) | KDRMETFLT1 | |
| SCHEMBL3569226 | 0.81 | KDR (0.51) | KDRMETFLT1 | |
| SCHEMBL18516612 | 0.79 | MET (0.67) | KDRMET | |
| SCHEMBL2539374 | 0.78 | MET (0.59) | KDRMETFLT1 | |
| SCHEMBL5585964 | 0.77 | KDR (0.44) | KDRMETFLT1 | |
| SCHEMBL10224369 | 0.76 | KDR (0.53) | KDRMETFLT1 | |
| SCHEMBL15241390 | 0.75 | KDR (0.70) | KDRMETFLT1 | |
| SCHEMBL10224378 | 0.73 | KDR (0.50) | KDRMETFLT1 | |
| SCHEMBL307495 | 0.73 | MET (0.68) | KDRMET | |
| SCHEMBL10272791 | 0.73 | GRIN3B (0.46) | KDRMETFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957498-A2 | INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING | MethylGene Inc. (CA) | 2008-08-20 | — | — | EP | claimed |
| WO-2008041053-A2 | INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING | METHYLGENE, INC. (CA) | 2008-04-10 | — | — | WO | claimed |
| US-20070004675-A1 | Inhibitors of VEGF receptor and HGF receptor signaling | METHYLGENE, INC. | 2007-01-04 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004675-A1 | Inhibitors of VEGF receptor and HGF receptor signaling | HGF, MET, FLT1 | KDR 4/4885MET 2/4885FLT1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.