Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11318964 | 0.98 | MEN1 (0.40) | MEN1KMT2AHCAR2GAAMAPT | |
| SCHEMBL94372 | 0.98 | MEN1 (0.40) | MEN1KMT2AHCAR2GAAMAPT | |
| SCHEMBL5603217 | 0.98 | MEN1 (0.40) | MEN1KMT2AHCAR2GAAMAPT | |
| SCHEMBL5276698 | 0.94 | HCAR2 (0.44) | MEN1KMT2AHCAR2GAAMAPT | |
| SCHEMBL17485813 | 0.92 | MEN1 (0.39) | MEN1KMT2AHCAR2ALDH1A1PKM | |
| SCHEMBL19501783 | 0.90 | HCAR2 (0.38) | MEN1KMT2AHCAR2MAPTHCAR3 | |
| SCHEMBL4364997 | 0.88 | MEN1 (0.39) | MEN1KMT2AHCAR2GAAMAPT | |
| SCHEMBL5274721 | 0.88 | HCAR2 (0.39) | MEN1KMT2AHCAR2GAAMAPT | |
| SCHEMBL5279145 | 0.88 | HCAR2 (0.42) | MEN1KMT2AHCAR2GAAMAPT | |
| SCHEMBL931958 | 0.85 | HCAR2 (0.36) | MEN1KMT2AHCAR2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011049232-A1 | DIARYLTRIAZOLE DERIVATIVE AS INSECTICIDE, MITICIDE, NEMATICIDE OR SOIL PESTICIDE | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2011-04-28 | — | — | WO | claimed |
| US-7276567-B2 | Heterocyclic substituted metallocene compounds for olefin polymerization | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2007-10-02 | — | — | US | claimed |
| CN-113614222-A | Blood brain barrier in vitro | 麻省理工学院 | 2021-11-05 | — | — | CN | disclosed |
| CN-108794412-B | Preparation method of 4, 5-diaryl-2H-1, 2, 3-triazole compound | 海南师范大学 | 2020-06-30 | — | — | CN | disclosed |
| CN-108794412-A | A kind of preparation method of 4,5- diaryl -2H-1,2,3- triazole compounds | 海南师范大学 | 2018-11-13 | — | — | CN | disclosed |
| US-20170349638-A1 | COMPANION DIAGNOSTIC TOOL FOR PEPTIDOMIMETIC MACROCYCLES | AILERON THERAPEUTICS, INC. | 2017-12-07 | — | — | US | disclosed |
| EP-3125886-A1 | DISUBSTITUTED TRIAZOLE ANALOGS | Board of Trustees of the University of Arkansas (US) | 2017-02-08 | — | — | EP | disclosed |
| WO-2015153635-A1 | DISUBSTITUTED TRIAZOLE ANALOGS | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (US) | 2015-10-08 | — | — | WO | disclosed |
| EP-2078009-B1 | NEW FLUORENE DERIVATIVES, COMPOSITIONS CONTAINING THE SAME AND USE THEREOF AS INHIBITORS OF THE PROTEIN CHAPERONE HSP 90 | SANOFI SA (FR) | 2015-03-18 | — | — | EP | disclosed |
| EP-2313412-B1 | NOVEL DERIVATIVES OF PYRROLOINDOLE INHIBITORS OF HSP90, COMPOSITIONS CONTAINING SAME, AND USE THEREOF | SANOFI SA (FR) | 2013-01-02 | — | — | EP | disclosed |
| US-8309721-B2 | HSP90 inhibitory carbazole derivatives, compositions containing same and use thereof | SANOFI (FR) | 2012-11-13 | — | — | US | disclosed |
| WO-2009122034-A2 | NOVEL HSP90 INHIBITORY CARBAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME, AND USE THEREOF | SANOFI-AVENTIS (FR) | 2009-10-08 | — | — | WO | disclosed |
| CN-101528735-A | Novel fluorene derivatives, compositions containing them and use as chaperone protein HSP90 inhibitors | SANOFI AVENTIS (FR) | 2009-09-09 | — | — | CN | disclosed |
| EP-2078009-A1 | NEW FLUORENE DERIVATIVES, COMPOSITIONS CONTAINING THE SAME AND USE THEREOF AS INHIBITORS OF THE PROTEIN CHAPERONE HSP 90 | Sanofi-Aventis (FR) | 2009-07-15 | — | — | EP | disclosed |
| WO-2009004146-A2 | NOVEL HERBIMYCIN A ANALOGUE DERIVATIVES, COMPOSITIONS CONTAINING SAME AND USE THEREOF | SANOFI-AVENTIS (FR) | 2009-01-08 | — | — | WO | disclosed |
| US-20080255216-A1 | Diaryltriazoles as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase-1 | MERCK SHARP & DOHME CORP. | 2008-10-16 | — | — | US | disclosed |
| WO-2008049994-A1 | NEW FLUORENE DERIVATIVES, COMPOSITIONS CONTAINING THE SAME AND USE THEREOF AS INHIBITORS OF THE PROTEIN CHAPERONE HSP 90 | SANOFI-AVENTIS (FR) | 2008-05-02 | — | — | WO | disclosed |
| US-7276567-B2 | Heterocyclic substituted metallocene compounds for olefin polymerization | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2007-10-02 | — | — | US | disclosed |
| CN-1938286-A | Diaryltriazoles as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 | MERCK & CO INC (US) | 2007-03-28 | — | — | CN | disclosed |
| US-20050261449-A1 | Heterocyclic substituted metallocene compounds for olefin polymerization | EXXONMOBIL CHEMICAL PATENT INC. | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170349638-A1 | COMPANION DIAGNOSTIC TOOL FOR PEPTIDOMIMETIC MACROCYCLES | TP53, TP53BP1, VHL | MEN1 585/4885KMT2A 4061/4885HCAR2 3206/4885 |
| US-20080255216-A1 | Diaryltriazoles as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase-1 | HSD11B1, HSD11B2, HSD17B1 | MEN1 2786/4885KMT2A 3497/4885HCAR2 347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.