Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL68782 | 0.87 | HTR2A (0.46) | KDM4ETSHR | |
| SCHEMBL8775847 | 0.83 | CFTR (0.53) | SLC6A3SLC6A2SLC6A4LMNAEPHX2 | |
| SCHEMBL6698860 | 0.83 | CYP19A1 (0.55) | SLC6A3SLC6A2SLC6A4KMT2AAKT1 | |
| SCHEMBL3404988 | 0.81 | SLC6A2 (0.41) | SLC6A3SLC6A2SLC6A4LMNAEPHX2 | |
| SCHEMBL6256116 | 0.81 | SLC6A3 (0.52) | SLC6A3SLC6A2SLC6A4LMNAEPHX2 | |
| SCHEMBL6340019 | 0.78 | CHRNB2 (0.55) | SLC6A3SLC6A2SLC6A4LMNAALDH1A1 | |
| SCHEMBL28772579 | 0.78 | HTR2A (0.59) | SLC6A3SLC6A2SLC6A4ALDH1A1KMT2A | |
| SCHEMBL5995430 | 0.76 | CNR1 (0.45) | SLC6A3SLC6A2LMNAALDH1A1POLB | |
| SCHEMBL6701579 | 0.76 | IDO1 (0.46) | SLC6A3SLC6A2SLC6A4TSHR | |
| SCHEMBL6703510 | 0.76 | ACP3 (0.51) | SLC6A3SLC6A2SLC6A4ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1915361-A1 | ALKYLPYRIDYL QUINOLINES AS NK3 RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2008-04-30 | — | — | EP | disclosed |
| WO-2007018466-A1 | ALKYLPYRIDYL QUINOLINES AS NK3 RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2007-02-15 | — | — | WO | disclosed |