SCHEMBL4604850

SCHEMBL4604850

COC(=O)Oc1ccc2c(ccn2CCC(C)(C)N)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 6/20 0.50
MTNR1B P49286 6/20 0.50
HTR2C P28335 1/20 0.45
MAOA P21397 1/20 0.43
MAOB P27338 1/20 0.43
HDAC8 Q9BY41 3/20 0.41
HDAC6 Q9UBN7 3/20 0.41
HDAC3 O15379 2/20 0.41
HDAC1 Q13547 2/20 0.41
HDAC2 Q92769 2/20 0.41
NCOR2 Q9Y618 1/20 0.41
HDAC11 Q96DB2 1/20 0.41
MCL1 Q07820 3/20 0.39
BCL2 P10415 2/20 0.39
MEN1 O00255 1/20 0.39
NPC1 O15118 1/20 0.39
ALDH1A1 P00352 1/20 0.39
RAB9A P51151 1/20 0.39
KMT2A Q03164 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4604053 0.88 MTNR1A (0.46) MTNR1AMTNR1BHTR2CMAOAMAOB
SCHEMBL8463092 0.85 HTR2C (0.57) MTNR1AMTNR1BHTR2CHDAC8HDAC6
SCHEMBL2950735 0.82 HTR2C (0.44) MTNR1AMTNR1BHTR2CMAOAMAOB
SCHEMBL2951066 0.81 MCL1 (0.59) MCL1BCL2MEN1KMT2ASMN1; SMN2
SCHEMBL2947992 0.81 KDM4E (0.46) MTNR1AMTNR1BHDAC8HDAC6HDAC3
SCHEMBL27718498 0.76 PLG (0.48) HDAC8HDAC6HDAC11MCL1BCL2
SCHEMBL4617643 0.75 PLG (0.39) MTNR1AMTNR1BHTR2C
SCHEMBL4640487 0.74 KMT2A (0.41) MAOBMEN1ALDH1A1RAB9AKMT2A
SCHEMBL2949514 0.73 PLAU (0.45) MTNR1AMTNR1BHDAC8HDAC6HDAC11
SCHEMBL2950619 0.73 SMN1; SMN2 (0.57) MTNR1AMTNR1BHDAC8HDAC6HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1943220-A2 NOVEL INDOLE-CONTAINING BETA AGONISTS, METHOD FOR PRODUCING THEM AND THEIR USE AS DRUGS Boehringer Ingelheim International GmbH (DE) 2008-07-16 EP disclosed
WO-2007048841-A2 NOVEL INDOLE-CONTAINING BETA AGONISTS, METHOD FOR PRODUCING THEM AND THEIR USE AS DRUGS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2007-05-03 WO disclosed