Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GLA | P06280 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4640794 | 0.89 | MEN1 (0.38) | KMT2AMEN1RAB9ACALCRLHPGD | |
| SCHEMBL4640997 | 0.83 | MEN1 (0.36) | KMT2AMEN1RAB9ACALCRLHPGD | |
| SCHEMBL4915808 | 0.82 | KDM4E (0.53) | KMT2AMEN1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL1858719 | 0.74 | MAPT (0.47) | KMT2AMEN1MAOBKDM4EALDH1A1 | |
| SCHEMBL13082395 | 0.74 | MEN1 (0.35) | KMT2AMEN1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL4604850 | 0.74 | MTNR1A (0.50) | KMT2AMEN1RAB9ASMN1; SMN2MAOB | |
| SCHEMBL739035 | 0.73 | MEN1 (0.59) | KMT2AMEN1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL8125879 | 0.70 | KMO (0.55) | KMT2AMEN1CALCRLHPGDEPHX2 | |
| Trifluoroacetic Acid SCHEMBL4607803 | 0.70 | MEN1 (0.49) | KMT2AMEN1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL1858977 | 0.70 | DAO (0.50) | KMT2AMEN1CALCRLHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943229-A1 | BENZIMIDAZOLE DERIVATIVES FOR USE AS BETA-3 RECEPTOR AGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007048842-A1 | BENZIMIDAZOLE DERIVATIVES FOR USE AS BETA-3 RECEPTOR AGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-05-03 | — | — | WO | disclosed |