Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 13/20 | 0.64 |
| ▸ | GRIA2 | P42262 | 5/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.44 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4605328 | 1.00 | GRIA4 (0.64) | GRIA4GRIA2L3MBTL1CCR2KCNH2 | |
| SCHEMBL4605867 | 0.89 | GRIA4 (0.76) | GRIA4GRIA2KCNH2 | |
| SCHEMBL4605872 | 0.89 | GRIA4 (0.76) | GRIA4GRIA2KCNH2 | |
| SCHEMBL4607477 | 0.87 | GRIA4 (0.57) | GRIA4GRIA2KCNH2 | |
| SCHEMBL4607636 | 0.87 | GRIA4 (0.57) | GRIA4GRIA2KCNH2 | |
| SCHEMBL4605829 | 0.86 | GRIA4 (0.56) | GRIA4GRIA2KCNH2 | |
| SCHEMBL4607371 | 0.86 | GRIA4 (0.56) | GRIA4GRIA2KCNH2 | |
| SCHEMBL4607600 | 0.85 | GRIA4 (0.70) | GRIA4GRIA2 | |
| SCHEMBL4607075 | 0.85 | GRIA4 (0.70) | GRIA4GRIA2 | |
| SCHEMBL4606805 | 0.85 | GRIA4 (0.55) | GRIA4GRIA2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | claimed |
| US-6639107-B1 | Potentiating glutamate receptor function | ELI LILLY AND COMPANY | 2003-10-28 | — | — | US | claimed |
| EP-1246797-A1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-10-09 | — | — | EP | claimed |
| WO-2001042203-A1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2001-06-14 | — | — | WO | claimed |
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | disclosed |
| US-6639107-B1 | Potentiating glutamate receptor function | ELI LILLY AND COMPANY | 2003-10-28 | — | — | US | disclosed |
| EP-1246797-A1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001042203-A1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2001-06-14 | — | — | WO | disclosed |