Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 6/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9418015 | 1.00 | ALDH1A1 (0.46) | ALDH1A1GAALTA4HTSHRCA12 | |
| SCHEMBL9418021 | 1.00 | ALDH1A1 (0.46) | ALDH1A1GAALTA4HTSHRCA12 | |
| SCHEMBL7892665 | 0.96 | ALDH1A1 (0.48) | ALDH1A1GAALTA4HTSHRCA12 | |
| SCHEMBL12095500 | 0.91 | CA12 (0.53) | ALDH1A1GAATSHRCA12CA1 | |
| SCHEMBL9242706 | 0.87 | ALDH1A1 (0.45) | ALDH1A1GAA | |
| SCHEMBL4605698 | 0.85 | LTA4H (0.45) | ALDH1A1GAALTA4HTSHRCA12 | |
| SCHEMBL9237714 | 0.84 | ALDH1A1 (0.44) | ALDH1A1GAALTA4HTSHRCA12 | |
| SCHEMBL9237689 | 0.84 | ALDH1A1 (0.43) | ALDH1A1GAATSHRCA12CA1 | |
| SCHEMBL8051743 | 0.84 | S1PR3 (0.40) | TSHR | |
| SCHEMBL2224932 | 0.83 | LTA4H (0.64) | ALDH1A1LTA4HTSHRTP53PLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943287-A2 | MOLDING COMPOSITION AND METHOD, AND MOLDED ARTICLE | General Electric Company (US) | 2008-07-16 | — | — | EP | disclosed |
| US-7378455-B2 | A curable epoxy resin , two latent cationic curing catalyst, a free radical-producng cocatalyst and inorganic filler of about 70-95 weight % based on the total weight; catalyst allows the use of increased filler loadingsto reduce moisture absorption and thermal expansion; encapsulating solid state device | GENERAL ELECTRIC COMPANY (US) | 2008-05-27 | — | — | US | disclosed |
| WO-2007005280-A2 | MOLDING COMPOSITION AND METHOD, AND MOLDED ARTICLE | GENERAL ELECTRIC COMPANY (US) | 2007-01-11 | — | — | WO | disclosed |
| US-20070004819-A1 | A curable epoxy resin , two latent cationic curing catalyst, a free radical-producng cocatalyst and inorganic filler of about 70-95 weight % based on the total weight; catalyst allows the use of increased filler loadingsto reduce moisture absorption and thermal expansion; encapsulating solid state device | CITIBANK, N.A., AS COLLATERAL AGENT | 2007-01-04 | — | — | US | disclosed |
| EP-0795790-B1 | Peel-developable lithographic printing plate | KODAK POLYCHROME GRAPHICS LLC (US) | 2002-09-25 | — | — | EP | disclosed |
| EP-0730201-B1 | Sensitized photopolymerizable compositions and use thereof in lithographic printing plates | KODAK POLYCHROME GRAPHICS LLC (US) | 2001-05-09 | — | — | EP | disclosed |
| US-6153661-A | POLYMERIZABLE OR CROSSLINKABLE MONOMER OR POLYMER COMPRISING EPOXY GROUP(S) OR VINYL ETHER GROUP(S) | RHONE-POULENC CHIMIE (FR) | 2000-11-28 | — | — | US | disclosed |
| US-6147184-A | NONTOXIC, EFFICIENT PHOTOINITIATOR | RHONE-POULENC CHIMIE (FR) | 2000-11-14 | — | — | US | disclosed |
| US-5942372-A | COMPRISED A SPECTRAL SENSITIZER THAT SENSITIZES IN THE ULTRAVIOLET OR VISIBLE REGIONS OF THE SPECTRUM AND AN N-ARYL POLYCARBOXYLIC ACID CO-INITIATOR; VERY HIGH PHOTOSPEED AND VERY GOOD SHELF-LIFE IN COMPUTER-TO-PLATE SYSTEMS | KODAK POLYCHROME GRAPHICS, LLC (US) | 1999-08-24 | — | — | US | disclosed |
| US-5914215-A | ELEMENT COMPRISING SUPPORT HAVING PHOTOIMAGEABLE, RADIATION SENSITIVE LAYER COMPRISING UNSATURATED COMPOUND, PHOTOINITIATOR SYSTEM COMPRISING SENSITIZER SENSITIZING IN ULTRAVIOLET OR VISIBLE REGION OF SPECTRUM, CO-INITIATOR | KODAK POLYCHROME GRAPHIC, LLC (US) | 1999-06-22 | — | — | US | disclosed |
| US-5468902-A | Onium borates/borates of organometallic complexes and cationic initiation of polymerization therewith | RHONE-POULENC CHIMIE (FR) | 1995-11-21 | — | — | US | disclosed |
| US-5340898-A | A mixtures comprising an ionic onium borate photoinitiators; nontoxic | RHONE-POULENC CHIMIE (FR) | 1994-08-23 | — | — | US | disclosed |
| EP-0404031-B1 | UV curable non-toxic epoxysilicone release coating compositions and method | GEN ELECTRIC (US) | 1994-05-04 | — | — | EP | disclosed |
| EP-0334056-B1 | Non-toxic aryl onium salts, UV curable coating compositions and food packaging use | GEN ELECTRIC (US) | 1994-02-02 | — | — | EP | disclosed |
| US-5082686-A | Alkylphenol, alkanediol, metalloid salt | GENERAL ELECTRIC COMPANY (US) | 1992-01-21 | — | — | US | disclosed |
| US-5010118-A | Using polyarylonium salt catalyst | GENERAL ELECTRIC COMPANY (US) | 1991-04-23 | — | — | US | disclosed |
| US-4981881-A | Non-toxic aryl onium salts, UV curable coating compositions and food packaging use | GENERAL ELECTRIC COMPANY (US) | 1991-01-01 | — | — | US | disclosed |
| EP-0404031-A1 | UV curable non-toxic epoxysilicone release coating compositions and method | GENERAL ELECTRIC COMPANY (US) | 1990-12-27 | — | — | EP | disclosed |
| US-4882201-A | Non-toxic aryl onium salts, UV curable coating compositions and food packaging use | GENERAL ELECTRIC COMPANY (US) | 1989-11-21 | — | — | US | disclosed |
| EP-0334056-A2 | Non-toxic aryl onium salts, UV curable coating compositions and food packaging use | GENERAL ELECTRIC COMPANY (US) | 1989-09-27 | — | — | EP | disclosed |