Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SENP5 | Q96HI0 | 6/20 | 0.44 |
| ▸ | SENP2 | Q9HC62 | 6/20 | 0.44 |
| ▸ | SENP1 | Q9P0U3 | 6/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.43 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | EDNRA | P25101 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4604985 | 0.89 | CXCR2 (0.54) | CXCR2MAPTKMT2AF2LMNA | |
| SCHEMBL4604550 | 0.88 | CXCR2 (0.59) | CXCR2MAPTKMT2ARXFP1ALDH1A1 | |
| SCHEMBL4634470 | 0.88 | CXCR2 (0.53) | CXCR2MAPTRXFP1ALDH1A1LMNA | |
| SCHEMBL4634975 | 0.81 | CXCR2 (0.52) | CXCR2MAPTRXFP1ALDH1A1LMNA | |
| SCHEMBL4635005 | 0.80 | CXCR2 (0.46) | CXCR2MAPTKMT2ARXFP1ALDH1A1 | |
| SCHEMBL4605692 | 0.79 | CXCR2 (0.50) | CXCR2MAPTKMT2AF2RXFP1 | |
| SCHEMBL4635007 | 0.79 | CXCR2 (0.49) | CXCR2KMT2ARXFP1ALDH1A1LMNA | |
| SCHEMBL4604056 | 0.79 | PTPN1 (0.60) | CXCR2MAPTKMT2AF2ALDH1A1 | |
| SCHEMBL4633866 | 0.79 | CXCR2 (0.67) | CXCR2MAPTKMT2ARXFP1ALDH1A1 | |
| SCHEMBL4604123 | 0.78 | CXCR2 (0.49) | CXCR2MAPTKMT2AF2RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685122-B1 | BENZOFURANS AND BENZOTHIOPHENES | MERCK PATENT GMBH (DE) | 2008-07-09 | — | — | EP | disclosed |
| US-7371774-B2 | Benzofurans and benzothiophenes | MERCK PATENT GMBH (DE) | 2008-05-13 | — | — | US | disclosed |
| US-20070066680-A1 | Benzofurans and benzothiophenes | MERCK PATENT GMBH (DE) | 2007-03-22 | — | — | US | disclosed |
| EP-1685122-A1 | BENZOFURANS AND BENZOTHIOPHENES | MERCK PATENT GmbH (DE) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005054226-A1 | BENZOFURANS AND BENZOTHIOPHENES | MERCK PATENT GMBH (DE) | 2005-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066680-A1 | Benzofurans and benzothiophenes | INSR, GPR119, IGF1R | CXCR2 1633/4885MAPT 1767/4885KMT2A 2846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.