Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | BAD | Q92934 | 1/20 | 0.39 |
| ▸ | SENP5 | Q96HI0 | 2/20 | 0.38 |
| ▸ | SENP2 | Q9HC62 | 2/20 | 0.38 |
| ▸ | SENP1 | Q9P0U3 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4828979 | 0.89 | CXCR2 (0.57) | CXCR2LMNAPPARGPPARD | |
| SCHEMBL4606015 | 0.88 | CXCR2 (0.56) | CXCR2MAPTRXFP1ALDH1A1LMNA | |
| SCHEMBL4604234 | 0.87 | CXCR2 (0.56) | CXCR2MAPTRXFP1ALDH1A1LMNA | |
| SCHEMBL4606075 | 0.87 | CXCR2 (0.61) | CXCR2MAPTRXFP1ALDH1A1LMNA | |
| SCHEMBL4634470 | 0.85 | CXCR2 (0.53) | CXCR2MAPTRXFP1ALDH1A1LMNA | |
| SCHEMBL4602716 | 0.82 | CXCR2 (0.54) | CXCR2MAPTRXFP1ALDH1A1LMNA | |
| SCHEMBL4604246 | 0.81 | CXCR2 (0.53) | CXCR2MAPTRXFP1ALDH1A1LMNA | |
| SCHEMBL4605238 | 0.80 | CXCR2 (0.52) | CXCR2MAPTRXFP1ALDH1A1LMNA | |
| SCHEMBL4634975 | 0.79 | CXCR2 (0.52) | CXCR2MAPTRXFP1ALDH1A1LMNA | |
| SCHEMBL4635005 | 0.78 | CXCR2 (0.46) | CXCR2MAPTRXFP1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685122-B1 | BENZOFURANS AND BENZOTHIOPHENES | MERCK PATENT GMBH (DE) | 2008-07-09 | — | — | EP | disclosed |
| US-7371774-B2 | Benzofurans and benzothiophenes | MERCK PATENT GMBH (DE) | 2008-05-13 | — | — | US | disclosed |
| US-20070066680-A1 | Benzofurans and benzothiophenes | MERCK PATENT GMBH (DE) | 2007-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066680-A1 | Benzofurans and benzothiophenes | INSR, GPR119, IGF1R | CXCR2 1633/4885MAPT 1767/4885RXFP1 101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.