Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MARS1 | P56192 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | GLS | O94925 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4605614 | 0.87 | CES1 (0.45) | RAB9AKMT2AHDAC1HDAC2MEN1 | |
| SCHEMBL4166185 | 0.85 | NPC1 (0.42) | POLBRAB9AKMT2ANPC1TDP1 | |
| Trifluoroacetic Acid SCHEMBL4169498 | 0.83 | HDAC4 (0.39) | L3MBTL1HDAC1HDAC2 | |
| SCHEMBL4174445 | 0.81 | HDAC1 (0.42) | POLBRAB9AKMT2ANPC1HDAC1 | |
| Trifluoroacetic Acid SCHEMBL4160622 | 0.81 | PADI4 (0.39) | POLBGLSHDAC1HDAC2CES1 | |
| SCHEMBL4174424 | 0.81 | SIGMAR1 (0.38) | L3MBTL1KMT2AHDAC1HDAC2MEN1 | |
| SCHEMBL4605724 | 0.80 | CES1 (0.46) | HDAC1HDAC2CES1 | |
| SCHEMBL4164039 | 0.78 | HDAC1 (0.41) | POLBKMT2AHDAC1HDAC2MEN1 | |
| Trifluoroacetic Acid SCHEMBL4166937 | 0.78 | FABP4 (0.36) | KMT2AHDAC1HDAC2MEN1CES1 | |
| SCHEMBL3507605 | 0.77 | GPR139 (0.42) | L3MBTL1KMT2AHDAC1HDAC2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945609-A2 | AMINO ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007029036-A2 | AMINO ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-03-15 | — | — | WO | disclosed |