Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7144417 | 0.79 | HTR6 (0.52) | HTR6KDM4EPKMALDH1A1MET | |
| SCHEMBL4637602 | 0.79 | HTR6 (0.45) | HTR6KDM4EPKMALDH1A1MET | |
| SCHEMBL5224094 | 0.76 | NPSR1 (0.45) | HTR6KDM4EPKMALDH1A1MET | |
| SCHEMBL16882344 | 0.75 | HTR6 (0.45) | HTR6KDM4EALDH1A1AKR1B1ABCB1 | |
| SCHEMBL2921045 | 0.71 | TRPV4 (0.32) | ALDH1A1 | |
| SCHEMBL27678863 | 0.70 | KMT2A (0.54) | HTR6KDM4EPKMALDH1A1MET | |
| SCHEMBL8080841 | 0.69 | HTR6 (0.72) | HTR6KDM4EALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL1713160 | 0.69 | HTR6 (0.57) | HTR6KDM4EALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL4400959 | 0.69 | HTR6 (0.56) | HTR6KDM4EPKMALDH1A1SMN1; SMN2 | |
| SCHEMBL31092469 | 0.69 | HTR6 (0.57) | HTR6KDM4EALDH1A1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943241-A1 | PYRAZOLES USEFUL IN THE TREATMENT OF INFLAMMATION | Biolipox AB (SE) | 2008-07-16 | — | — | EP | disclosed |
| EP-1937645-A1 | PYRAZOLES USEFUL IN THE TREATMENT OF INFLAMMATION | Biolipox AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007051981-A1 | PYRAZOLES USEFUL IN THE TREATMENT OF INFLAMMATION | BIOLIPOX AB (SE) | 2007-05-10 | — | — | WO | disclosed |
| WO-2007045868-A1 | PYRAZOLES USEFUL IN THE TREATMENT OF INFLAMMATION | BIOLIPOX AB (SE) | 2007-04-26 | — | — | WO | disclosed |