Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 10/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4607220 | 0.86 | ADRB3 (0.48) | ADRB3ADRB2ADRB1DNM1HTR2A | |
| SCHEMBL4795725 | 0.84 | ADRB2 (0.49) | ADRB3ADRB2ADRB1DNM1HTR2A | |
| SCHEMBL4643608 | 0.82 | ADRB3 (0.46) | ADRB3ADRB2ADRB1DNM1HTR2A | |
| SCHEMBL4607514 | 0.82 | ADRB3 (0.49) | ADRB3ADRB2ADRB1DNM1HTR2A | |
| SCHEMBL2994681 | 0.78 | ADRB3 (0.64) | ADRB3ADRB2ADRB1SIGMAR1DNM1 | |
| SCHEMBL4457452 | 0.77 | ADRB2 (0.53) | ADRB3ADRB2ADRB1DNM1HTR2A | |
| SCHEMBL4696496 | 0.76 | ALDH1A1 (0.41) | ADRB3ADRB2ADRB1 | |
| SCHEMBL7702692 | 0.75 | ADRB3 (0.67) | ADRB3ADRB2ADRB1DNM1 | |
| SCHEMBL7701306 | 0.74 | ADRB3 (0.68) | ADRB3ADRB2ADRB1DNM1 | |
| SCHEMBL4608341 | 0.74 | ADRB2 (0.53) | ADRB3ADRB2ADRB1DNM1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945612-A2 | HETEROCYCLIC COMPOUNDS AS PSTAT3/IL-6 INHIBITORS | Orchid Research Laboratories Limited (IN) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007042912-A2 | HETEROCYCLIC COMPOUNDS AS PSTAT3/IL-6 INHIBITORS | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2007-04-19 | — | — | WO | disclosed |