SCHEMBL4607151

SCHEMBL4607151

Cc1c[c]c(Cl)c(-c2cccc(C(F)(F)C(F)(F)F)c2)c1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN5 P54829 5/20 0.34
RORC P51449 3/20 0.33
RORB Q92753 3/20 0.33
HPGD P15428 3/20 0.31
MEN1 O00255 2/20 0.31
KMT2A Q03164 2/20 0.31
KDM4E B2RXH2 2/20 0.31
ALDH1A1 P00352 2/20 0.31
CYP1A2 P05177 2/20 0.31
CYP3A4 P08684 2/20 0.31
HSD17B10 Q99714 2/20 0.31
NPC1 O15118 1/20 0.31
THRB P10828 1/20 0.31
CYP2C9 P11712 1/20 0.31
PKM P14618 1/20 0.31
TSHR P16473 1/20 0.31
STAT6 P42226 1/20 0.31
HTT P42858 1/20 0.31
RAB9A P51151 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5138592 0.86 PTPN5 (0.34) PTPN5HPGDMEN1KMT2AKDM4E
SCHEMBL4608305 0.79 RORC (0.34) PTPN5RORCRORBHPGDMEN1
SCHEMBL4608309 0.78 RORB (0.36) PTPN5RORCRORBHPGDMEN1
SCHEMBL4607153 0.78 RORC (0.33) PTPN5RORCRORBHPGDMEN1
SCHEMBL5138594 0.72 BRD4 (0.32) PTPN5MEN1KMT2A
SCHEMBL4606814 0.71 RORB (0.43) RORCRORBHPGDMEN1KMT2A
SCHEMBL5085691 0.68 PTPN5 (0.34) PTPN5
SCHEMBL3277997 0.68 ACHE (0.48) PTPN5MEN1KMT2AALDH1A1CYP1A2
SCHEMBL29749591 0.68 ACHE (0.48) PTPN5MEN1KMT2AALDH1A1CYP1A2
SCHEMBL8307164 0.67 RORB (0.44) RORCRORBHPGDMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008091594-A2 FUNGICIDAL MIXTURES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2008-07-31 WO disclosed
EP-1948649-A2 FUNGICIDAL CARBOXAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2008-07-30 EP disclosed
WO-2007014290-A2 FUNGICIDAL CARBOXAMIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2007-02-01 WO disclosed