Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.43 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.43 |
| ▸ | ADCY2 | Q08462 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4607494 | 1.00 | MEN1 (0.45) | MEN1KMT2ASLC6A9SLC6A5SLC6A2 | |
| SCHEMBL4607545 | 0.89 | SCN1A (0.44) | SLC6A9SLC6A5KDM4EALDH1A1 | |
| SCHEMBL4607546 | 0.89 | SCN1A (0.44) | SLC6A9SLC6A5KDM4EALDH1A1 | |
| SCHEMBL25341814 | 0.86 | RAB9A (0.44) | MEN1KMT2ASLC6A9SLC6A5SLC6A2 | |
| SCHEMBL4607816 | 0.86 | MEN1 (0.44) | MEN1KMT2AALDH1A1GAAGRIA4 | |
| SCHEMBL28817110 | 0.86 | MEN1 (0.44) | MEN1KMT2AALDH1A1GAAGRIA4 | |
| SCHEMBL28817077 | 0.86 | MEN1 (0.44) | MEN1KMT2AALDH1A1GAAGRIA4 | |
| SCHEMBL31330266 | 0.77 | KDM1A (0.43) | MEN1KMT2ASLC6A4SLC6A3KDM4E | |
| SCHEMBL757194 | 0.76 | LMNA (0.46) | MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6659482 | 0.71 | SLC18A3 (0.44) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | disclosed |
| US-6639107-B1 | Potentiating glutamate receptor function | ELI LILLY AND COMPANY | 2003-10-28 | — | — | US | disclosed |
| EP-1246797-A1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001042203-A1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2001-06-14 | — | — | WO | disclosed |