Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | PPARA | Q07869 | 3/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2651107 | 0.87 | MAOB (0.44) | ALDH1A1KCNH2TMEM97FDFT1 | |
| SCHEMBL28185303 | 0.86 | ALDH1A1 (0.41) | ALDH1A1KCNH2TMEM97TAAR1NPC1 | |
| SCHEMBL5225928 | 0.85 | TAAR1 (0.50) | ALDH1A1KCNH2TMEM97TAAR1NPC1 | |
| SCHEMBL3655150 | 0.85 | TAAR1 (0.50) | ALDH1A1KCNH2TMEM97TAAR1NPC1 | |
| SCHEMBL28265221 | 0.83 | FFAR2 (0.40) | ALDH1A1KCNH2TMEM97TAAR1NPC1 | |
| SCHEMBL19407026 | 0.82 | ALDH1A1 (0.44) | ALDH1A1KCNH2TMEM97TAAR1NPC1 | |
| SCHEMBL11611907 | 0.81 | ALDH1A1 (0.42) | ALDH1A1KCNH2TMEM97TAAR1NPC1 | |
| SCHEMBL2652984 | 0.79 | MAOB (0.46) | ALDH1A1FDFT1 | |
| SCHEMBL13971048 | 0.79 | FFAR1 (0.50) | PPARGPPARAEPHX2SLC6A9L3MBTL1 | |
| SCHEMBL13003550 | 0.78 | ALDH1A1 (0.46) | ALDH1A1KCNH2TMEM97TAAR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948603-A1 | TETRAHYDROINDOLE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LTD. (GB) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007054739-A1 | TETRAHYDROINDOLE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2007-05-18 | — | — | WO | disclosed |