SCHEMBL4607653

SCHEMBL4607653

CC(Cc1cc(I)c(Oc2cc(I)c(O)cc2I)c(I)c1)C(=O)O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 12/20 0.48
THRA P10827 8/20 0.48
LMNA P02545 6/20 0.48
MEN1 O00255 6/20 0.48
KMT2A Q03164 6/20 0.48
PPARG P37231 5/20 0.48
PCNA P12004 5/20 0.48
ABCB11 O95342 2/20 0.48
GABRA1 P14867 2/20 0.48
GABRA2 P47869 2/20 0.48
GABRB2 P47870 2/20 0.48
CYP2D6 P10635 1/20 0.48
TSHR P16473 1/20 0.48
GABRP O00591 1/20 0.48
GABRD O14764 1/20 0.48
F2 P00734 1/20 0.48
GABRB1 P18505 1/20 0.48
GABRG2 P18507 1/20 0.48
GABRB3 P28472 1/20 0.48
ADORA1 P30542 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3222206 0.81 THRB (0.73) THRBTHRALMNAMEN1KMT2A
SCHEMBL3217395 0.80 THRB (0.73) THRBTHRALMNAMEN1KMT2A
SCHEMBL1525944 0.79 THRB (0.63) THRBTHRALMNAMEN1KMT2A
SCHEMBL4453017 0.78 THRB (0.46) THRBTHRALMNAMEN1KMT2A
SCHEMBL12758960 0.77 PCNA (0.72) THRBTHRALMNAMEN1KMT2A
SCHEMBL4238471 0.77 PCNA (0.65) THRBTHRALMNAMEN1KMT2A
SCHEMBL23964667 0.76 SIRT5 (0.55) THRBTHRALMNAMEN1KMT2A
SCHEMBL8733106 0.76 THRB (0.39) THRBTHRALMNAMEN1KMT2A
SCHEMBL12200628 0.74 FOLH1 (0.59) THRBTHRALMNAMEN1KMT2A
SCHEMBL6041111 0.73 THRB (0.40) THRBTHRALMNAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040234592-A1 Mixture containing thyroid hormone , ethanolamine and emulsifier KARO BIO AB (SE) 2004-11-25 US claimed
EP-1398024-A2 Uses for thyroid hormone compounds KARO BIO AB (SE) 2004-03-17 EP claimed
EP-0831769-B1 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS KAROBIO AB (SE) 2003-10-15 EP claimed
EP-1328265-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE AGONIST COMPOUNDS FOR TREATING DERMIS CONDITIONS KARO BIO AB (SE) 2003-07-23 EP claimed
US-20020123521-A1 Treatment for dermal skin atrophy using thyroid hormone compounds or thyroid hormone-like compounds KOO, CATHERINE, DR 2002-09-05 US claimed
WO-2002005834-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE AGONIST COMPOUNDS FOR TREATING DERMIS CONDITIONS KARO BIO AB (SE) 2002-01-24 WO claimed
US-6221911-B1 REDUCING SUBCUTANEOUS FAT DEPOSITS IN A SUBJECT; IMPROVING THE SKIN CONDITION OF A SUBJECT KARO BIO AB (SE) 2001-04-24 US claimed
EP-0831769-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS KARO BIO AB (SE) 1998-04-01 EP claimed
WO-1996040048-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS KARO BIO AB (SE) 1996-12-19 WO claimed
EP-0831769-B2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS LAVIN DR THOMAS N (US) 2008-07-23 EP disclosed
US-20060292194-A1 Treatment for burns and adipose deposits using thyroid hormone compound in a human KOO, CATHERINE, DR 2006-12-28 US disclosed
US-20040234592-A1 Mixture containing thyroid hormone , ethanolamine and emulsifier KARO BIO AB (SE) 2004-11-25 US disclosed
EP-1404413-A2 DERMATOLOGICAL FORMULATIONS KARO BIO AB (SE) 2004-04-07 EP disclosed
EP-1398024-A2 Uses for thyroid hormone compounds KARO BIO AB (SE) 2004-03-17 EP disclosed
EP-1328265-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE AGONIST COMPOUNDS FOR TREATING DERMIS CONDITIONS KARO BIO AB (SE) 2003-07-23 EP disclosed
WO-2002089917-A2 DERMATOLOGICAL FORMULATIONS KARO BIO AB (SE) 2002-11-14 WO disclosed
US-20020123521-A1 Treatment for dermal skin atrophy using thyroid hormone compounds or thyroid hormone-like compounds KOO, CATHERINE, DR 2002-09-05 US disclosed
US-6380255-B1 TOPICALLY APPLYING TO SKIN THYROID HORMONE COMPOUND TOGETHER WITH A BASE FOR THERAPY OF SKIN ATROPHY KARO BIO AB (SE) 2002-04-30 US disclosed
WO-2002005834-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE AGONIST COMPOUNDS FOR TREATING DERMIS CONDITIONS KARO BIO AB (SE) 2002-01-24 WO disclosed
US-6221911-B1 REDUCING SUBCUTANEOUS FAT DEPOSITS IN A SUBJECT; IMPROVING THE SKIN CONDITION OF A SUBJECT KARO BIO AB (SE) 2001-04-24 US disclosed