Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 9/20 | 0.42 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28478970 | 1.00 | DNM1 (0.42) | DNM1PSMD14PLA2G1BMMP2RAD52 | |
| Hydrochloric Acid SCHEMBL29078674 | 1.00 | DNM1 (0.42) | DNM1PSMD14PLA2G1BMMP2RAD52 | |
| Hydrochloric Acid SCHEMBL30211833 | 1.00 | DNM1 (0.42) | DNM1PSMD14PLA2G1BMMP2RAD52 | |
| Hydrochloric Acid SCHEMBL28336675 | 1.00 | DNM1 (0.42) | DNM1PSMD14PLA2G1BMMP2RAD52 | |
| Hydrochloric Acid SCHEMBL1701782 | 1.00 | DNM1 (0.42) | DNM1PSMD14PLA2G1BMMP2RAD52 | |
| Hydrochloric Acid SCHEMBL114418 | 1.00 | DNM1 (0.42) | DNM1PSMD14PLA2G1BMMP2RAD52 | |
| Hydrochloric Acid SCHEMBL28467736 | 1.00 | DNM1 (0.42) | DNM1PSMD14PLA2G1BMMP2RAD52 | |
| Hydrochloric Acid SCHEMBL9465437 | 1.00 | DNM1 (0.42) | DNM1PSMD14PLA2G1BMMP2RAD52 | |
| Hydrochloric Acid SCHEMBL21253135 | 1.00 | DNM1 (0.42) | DNM1PSMD14PLA2G1BMMP2RAD52 | |
| Hydrochloric Acid SCHEMBL117037 | 1.00 | DNM1 (0.42) | DNM1PSMD14PLA2G1BMMP2RAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1946799-B1 | Silicone copolymer and cosmetics comprising the same | SHINETSU CHEMICAL CO (JP) | 2014-10-22 | — | — | EP | disclosed |
| EP-1946799-A2 | Silicone copolymer and cosmetics comprising the same | Shin-Etsu Chemical Co., Ltd. (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-5665338-A | KERATIN-REDUCING SUBSTANCE, NONIONIC AMPHIPHATIC COMPOUND | KAO CORPORATION (JP) | 1997-09-09 | — | — | US | disclosed |
| US-5587155-A | COMPRISING A FATTY ACID, POLYHYDRIC ALCOHOL, AROMATIC ALCOHOL AND AT LEAST ONE QUATERNARY AMMONIUM COMPOUND; HAIR CONDITIONERS | KAO CORPORATION (JP) | 1996-12-24 | — | — | US | disclosed |
| US-5045530-A | Conprising a micelle or a vesicle of a cationic teniside based on a hydrophobic alkyl-substituted pyridinium compound and a hydrophobic drug; drug delivery; skin disorders | MEDICI CHEM.-PHARM. FABRIK PUTTER GMBH (DE) | 1991-09-03 | — | — | US | disclosed |
| EP-0178009-B1 | PROCESS FOR RECONDITIONING CONTAMINATED SOIL | Heidemij Uitvoering B.V. (NL) | 1990-04-11 | — | — | EP | disclosed |
| EP-0178009-A1 | Process for reconditioning contaminated soil | Heidemij Uitvoering B.V. (NL) | 1986-04-16 | — | — | EP | disclosed |