Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | ANPEP | P15144 | 1/20 | 0.31 |
| ▸ | IL1RN | P18510 | 1/20 | 0.31 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.31 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6367893 | 0.94 | CHRNB4 (0.35) | ALDH1A1TSHRCHRNB4CHRNA3 | |
| SCHEMBL28911580 | 0.76 | HRH3 (0.46) | ALDH1A1HRH2HRH3 | |
| SCHEMBL2013779 | 0.74 | ALDH1A1 (0.33) | ALDH1A1ALOX15TSHRCHRNB4CHRNA3 | |
| SCHEMBL5485555 | 0.74 | ALDH1A1 (0.36) | ALDH1A1ALOX15TSHRCHRNB4CHRNA3 | |
| SCHEMBL14973844 | 0.74 | ALDH1A1 (0.42) | ALDH1A1MAPK1 | |
| SCHEMBL15758247 | 0.72 | IGF1R (0.46) | ALDH1A1ALOX15 | |
| SCHEMBL16817775 | 0.71 | MAPT (0.41) | ALDH1A1ALOX15TSHR | |
| SCHEMBL7700085 | 0.70 | CHRNB4 (0.41) | ALDH1A1CHRNB4CHRNA3ANPEPIL1RN | |
| SCHEMBL5534036 | 0.70 | HRH2 (0.41) | ALDH1A1CHRNB4CHRNA3HRH2HRH3 | |
| SCHEMBL7358858 | 0.69 | HTR6 (0.34) | HRH2HRH3PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | disclosed |
| US-6639107-B1 | Potentiating glutamate receptor function | ELI LILLY AND COMPANY | 2003-10-28 | — | — | US | disclosed |
| EP-1246797-A1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001042203-A1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2001-06-14 | — | — | WO | disclosed |