Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31583077 | 0.84 | ALDH1A1 (0.37) | ALOX15HTR2AHTR2CL3MBTL1ALDH1A1 | |
| SCHEMBL31116706 | 0.81 | SLC6A3 (0.57) | SLC6A2SLC6A3SLC6A4DPP4HTR2A | |
| SCHEMBL28013086 | 0.79 | SLC6A3 (0.44) | LMNASLC6A2SLC6A3SLC6A4DPP4 | |
| SCHEMBL28015330 | 0.77 | SLC6A3 (0.39) | LMNASLC6A2SLC6A3SLC6A4DPP4 | |
| SCHEMBL11681179 | 0.76 | HDAC4 (0.47) | LMNAALOX15SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL27631594 | 0.75 | MEN1 (0.38) | LMNASLC6A2SLC6A3SLC6A4DPP4 | |
| SCHEMBL15862743 | 0.74 | SLC6A3 (0.68) | ALOX15SLC6A2SLC6A3SLC6A4NPSR1 | |
| SCHEMBL5500843 | 0.74 | CA2 (0.39) | LMNAALOX15SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL28168405 | 0.74 | CETP (0.38) | SLC6A2SLC6A3SLC6A4HDAC4 | |
| SCHEMBL23649271 | 0.74 | OPRL1 (0.40) | HTR2AHTR2CHDAC4PDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | disclosed |
| EP-1390072-A2 | USE OF AN AMPA RECEPTOR POTENTIATOR FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF TYPE 2 DIABETES | ELI LILLY AND COMPANY (US) | 2004-02-25 | — | — | EP | disclosed |
| US-6639107-B1 | Potentiating glutamate receptor function | ELI LILLY AND COMPANY | 2003-10-28 | — | — | US | disclosed |
| WO-2002089848-A2 | USE OF AN AMPA RECEPTOR POTENTIATOR FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF TYPE 2 DIABETES | ELI LILLY AND COMPANY (US) | 2002-11-14 | — | — | WO | disclosed |
| EP-1246797-A1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001042203-A1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2001-06-14 | — | — | WO | disclosed |