Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5311228 | 1.00 | CA1 (0.41) | CA1CA9BBOX1CA4FAHD1 | |
| Fumaric Acid SCHEMBL122162 | 0.96 | — | — | |
| Fumaric Acid SCHEMBL27484728 | 0.96 | CA1 (0.43) | CA1CA9BBOX1CA4FAHD1 | |
| Fumaric Acid SCHEMBL372273 | 0.96 | — | — | |
| Fumaric Acid SCHEMBL122164 | 0.96 | — | — | |
| Fumaric Acid SCHEMBL30895862 | 0.96 | CA1 (0.43) | CA1CA9BBOX1CA4FAHD1 | |
| Fumaric Acid SCHEMBL23406301 | 0.92 | CA1 (0.41) | CA1CA9BBOX1CA4FAHD1 | |
| Fumaric Acid SCHEMBL17350111 | 0.92 | CA1 (0.41) | CA1CA9BBOX1CA4FAHD1 | |
| Fumaric Acid SCHEMBL10873090 | 0.92 | CA1 (0.41) | CA1CA9BBOX1CA4FAHD1 | |
| Fumaric Acid SCHEMBL22463124 | 0.92 | CA1 (0.41) | CA1CA9BBOX1CA4FAHD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018044895-A1 | IMMEDIATE RELEASE DOSAGE FORMS WITH ABUSE DETERRENCE AND ALCOHOL RESISTANCE | CIMA LABS INC. (US) | 2018-03-08 | — | — | WO | disclosed |
| US-8523975-B2 | Salts of mineral nutrients stabilized with amino acids and/or ammonium salt, products and food supplements that contain them and procedures for obtaining same | ETTLIN EDUARDO WALTER (AR) | 2013-09-03 | — | — | US | disclosed |
| US-20080314107-A1 | Salts of Mineral Nutrients Stabilized With Amino Acids and/or Ammonium Salt, Products and Food Supplement That Contain Them and Procedures of Obtention | ETTLIN EDUARDO WALTER | 2008-12-25 | — | — | US | disclosed |
| EP-1949799-A2 | SALTS OF MINERAL NUTRIENTS STABILIZED WITH AMINO ACIDS AND/OR AMMONIUM SALTS, PRODUCTS AND FOOD SUPPLEMENTS THAT CONTAIN THEM AND METHODS FOR OBTAINING SAME | Ettlin, Eduardo Walter (AR) | 2008-07-30 | — | — | EP | disclosed |
| US-20070178140-A1 | COMPOSITIONS AND METHODS FOR REDUCING FOOD INTAKE AND CONTROLLING WEIGHT | MCNEIL NUTRITIONALS, LLC | 2007-08-02 | — | — | US | disclosed |
| US-20070151569-A1 | METHODS FOR ACHIEVING AND MAINTAINING WEIGHT LOSS | MCNEIL NUTRITIONALS, LLC | 2007-07-05 | — | — | US | disclosed |
| WO-2007044737-A2 | COMPOSITIONS AND METHODS FOR REDUCING BLOOD GLUCOSE OR INSULIN AFTER A MEAL AND TREATING OR PREVENTING DIABETES | MCNEIL NUTRITIONALS LLC (US) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007044664-A1 | COMPOSITIONS AND METHODS FOR REDUCING FOOD INTAKE AND CONTROLLING WEIGHT | MCNEIL NUTRITIONALS, LLC (US) | 2007-04-19 | — | — | WO | disclosed |
| US-20070082026-A1 | Compositions and methods for reducing food intake and controlling weight | MCNEIL NUTRITIONALS, LLC | 2007-04-12 | — | — | US | disclosed |
| US-20070082025-A1 | Methods for achieving and maintaining weight loss | MCNEIL NUTRITIONALS, LLC | 2007-04-12 | — | — | US | disclosed |
| US-20070082085-A1 | Compositions and methods for reducing food intake and controlling weight | MCNEIL NUTRITIONALS, LLC | 2007-04-12 | — | — | US | disclosed |
| US-20070003672-A1 | Tri-part calcium fortified compositions and methods of making the same | COCO-COLA COMPANY | 2007-01-04 | — | — | US | disclosed |
| US-20070003671-A1 | Two-part calcium fortified compositions and methods of making the same | COCO-COLA COMPANY | 2007-01-04 | — | — | US | disclosed |
| US-6758872-B2 | DISPERSION OF ABRASIVE GRAINS COMPRISNG COMPOUNDS OF CERIUM, COPPER, AND/OR AMMONIUM | HITACHI, LTD. (JP) | 2004-07-06 | — | — | US | disclosed |
| US-6656022-B2 | Abrasive grains having remained after polishing are easily removed | HITACHI, LTD. (JP) | 2003-12-02 | — | — | US | disclosed |
| US-6656021-B2 | Process for fabricating a semiconductor device | HITACHI, LTD. (JP) | 2003-12-02 | — | — | US | disclosed |
| US-20020090894-A1 | Method for polishing a semiconductor substrate member | RENESAS ELECTRONICS CORPORATION (JP) | 2002-07-11 | — | — | US | disclosed |
| US-20020034925-A1 | Process for fabricating a semiconductor device | RENESAS ELECTRONICS CORPORATION (JP) | 2002-03-21 | — | — | US | disclosed |
| US-20020004360-A1 | Polishing slurry | RENESAS ELECTRONICS CORPORATION (JP) | 2002-01-10 | — | — | US | disclosed |
| WO-1994012624-A1 | CRYSTAL CARRIERS FOR CELL CULTURE | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 1994-06-09 | — | — | WO | disclosed |