Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 1/20 | 0.39 |
| ▸ | TOP1 | P11387 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | IDH2 | P48735 | 15/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4608126 | 0.86 | CETP (0.39) | CETPTOP1DRD2IDH2POLB | |
| SCHEMBL4224980 | 0.83 | PRKAB2 (0.41) | CETPTOP1DRD2IDH2POLB | |
| SCHEMBL4595686 | 0.82 | DRD2 (0.38) | DRD2 | |
| SCHEMBL4597024 | 0.80 | PTGS1 (0.34) | DRD2 | |
| SCHEMBL4596683 | 0.79 | PTGS1 (0.36) | DRD2 | |
| SCHEMBL4596880 | 0.79 | PTGS1 (0.37) | DRD2POLB | |
| SCHEMBL4760715 | 0.79 | HTR1A (0.43) | L3MBTL1 | |
| SCHEMBL4596618 | 0.79 | MAOB (0.39) | DRD2IDH2 | |
| SCHEMBL6047930 | 0.78 | DRD2 (0.33) | DRD2 | |
| SCHEMBL4597183 | 0.78 | PRKAB2 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874750-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth Incoporated (US) | 2008-01-09 | — | — | EP | disclosed |
| EP-1871355-A1 | NEW THERAPEUTIC COMBIANATIONS FOR THE TREATMENT OR PREVENTION OF DEPRESSION | Wyeth (US) | 2008-01-02 | — | — | EP | disclosed |
| EP-1871354-A1 | TREATMENT OF PAIN | Wyeth (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006116149-A1 | NEW THERAPEUTIC COMBIANATIONS FOR THE TREATMENT OR PREVENTION OF DEPRESSION | WYETH (US) | 2006-11-02 | — | — | WO | disclosed |
| WO-2006116171-A1 | TREATMENT OF PAIN | WYETH (US) | 2006-11-02 | — | — | WO | disclosed |