Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.45 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPY2R | P49146 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4608914 | 0.95 | SLC6A3 (0.47) | SLC6A3MBTD1L3MBTL3L3MBTL1SIGMAR1 | |
| SCHEMBL4624657 | 0.86 | HRH3 (0.48) | HRH3 | |
| SCHEMBL4624649 | 0.86 | HRH3 (0.48) | HRH3 | |
| SCHEMBL4608505 | 0.83 | HRH3 (0.53) | SLC6A3MBTD1L3MBTL3L3MBTL1SIGMAR1 | |
| SCHEMBL4610283 | 0.83 | KDM4E (0.45) | MBTD1L3MBTL3L3MBTL1HRH3 | |
| SCHEMBL4651854 | 0.82 | NPY1R (0.41) | NPY1RHTTNPY2R | |
| SCHEMBL4608119 | 0.81 | SLC6A3 (0.39) | SLC6A3MBTD1L3MBTL3L3MBTL1SIGMAR1 | |
| SCHEMBL4609111 | 0.81 | HRH3 (0.48) | HRH3 | |
| SCHEMBL4610443 | 0.81 | HRH3 (0.40) | SLC6A3NPY1RHTTNPY2RHRH3 | |
| SCHEMBL14538713 | 0.81 | HRH3 (0.48) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948605-A2 | MODULATORS OF THE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007061741-A2 | MODULATORS OF THE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007061741-A2 | MODULATORS OF THE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-05-31 | — | — | WO | disclosed |