Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.42 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PTGIR | P43119 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4624651 | 0.88 | ALDH1A1 (0.46) | HRH3KDM4EGAA | |
| SCHEMBL14538734 | 0.88 | ALDH1A1 (0.46) | HRH3KDM4EGAA | |
| SCHEMBL4608914 | 0.88 | SLC6A3 (0.47) | HRH3SIGMAR1MBTD1L3MBTL3L3MBTL1 | |
| SCHEMBL4607915 | 0.88 | ACHE (0.45) | HRH3MBTD1L3MBTL3L3MBTL1SLC6A4 | |
| SCHEMBL4608628 | 0.84 | HRH3 (0.42) | HRH3SIGMAR1MBTD1L3MBTL3L3MBTL1 | |
| SCHEMBL4610283 | 0.84 | KDM4E (0.45) | HRH3KDM4EMBTD1L3MBTL3L3MBTL1 | |
| SCHEMBL4610133 | 0.83 | HRH3 (0.44) | HRH3SIGMAR1MBTD1L3MBTL3L3MBTL1 | |
| SCHEMBL4608156 | 0.83 | SLC6A3 (0.46) | HRH3SIGMAR1MBTD1L3MBTL3L3MBTL1 | |
| SCHEMBL4607800 | 0.82 | HRH3 (0.39) | HRH3MBTD1L3MBTL3L3MBTL1 | |
| SCHEMBL4609186 | 0.81 | HRH3 (0.52) | HRH3SIGMAR1MBTD1L3MBTL3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948605-A2 | MODULATORS OF THE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2008-07-30 | — | — | EP | claimed |
| WO-2007061741-A2 | MODULATORS OF THE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-05-31 | — | — | WO | claimed |
| EP-1948605-A2 | MODULATORS OF THE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007061741-A2 | MODULATORS OF THE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007061741-A2 | MODULATORS OF THE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-05-31 | — | — | WO | disclosed |